Natural Zeitgebers Under Temperate Conditions Cannot Compensate for the Loss of a Functional Circadian Clock in Timing of a Vital Behavior in Drosophila

Natural Zeitgebers Under Temperate Conditions Cannot Compensate for the Loss of a Functional Circadian Clock in Timing of a Vital Behavior in Drosophila

Natural Zeitgebers Under Temperate Conditions Cannot Compensate for the Loss of a Functional Circadian Clock in Timing of a Vital Behavior in Drosophila

The adaptive significance of adjusting behavioral actions to the best time of the day appears apparent. Laboratory research implicated an essential position of circadian clocks in behavioral timing and rhythmicity. But, latest research on clock-mutant animals questioned this significance below extra naturalistic settings, as numerous clock mutants confirmed almost regular diel exercise rhythms below seminatural zeitgeber circumstances.
We right here report proof that correct timing of eclosion, a significant habits of the fruit fly Drosophila melanogaster, requires a purposeful molecular clock below quasi-natural circumstances. In distinction to wild-type flies, interval01 mutants with a faulty molecular clock confirmed impaired rhythmicity and gating in a temperate setting even within the presence of a full complement of abiotic zeitgebers. Though interval01 mutants nonetheless eclosed throughout a sure time window in the course of the day, this time window was a lot broader and loosely outlined, and rhythmicity was decrease or misplaced as categorized by numerous statistical measures. Furthermore, peak eclosion time turned extra inclined to variable day-to-day modifications of sunshine.
In distinction, flies with impaired peptidergic interclock signaling (Pdf01 and han5304 PDF receptor mutants) eclosed largely rhythmically with regular gate sizes, much like wild-type controls. Our outcomes recommend that the presence of pure zeitgebers isn’t adequate, and a purposeful molecular clock is required to induce steady temporal eclosion patterns in flies below temperate circumstances with appreciable day-to-day variation in gentle depth and temperature. Temperate zeitgebers are, nonetheless, adequate to functionally rescue a lack of PDF-mediated clock-internal and -output signaling.

Nanda-Hamner Curves Present Large Latitudinal Variation however No Circadian Elements in Drosophila Montana Photoperiodism

Insect species with a large distribution provide an important alternative to hint latitudinal variation within the photoperiodic regulation of traits essential in copy and stress tolerances. We measured this variation within the photoperiodic time-measuring system underlying reproductive diapause in Drosophila montana, utilizing a Nanda-Hamner (NH) protocol. Not one of the research strains confirmed diel rhythmicity in feminine diapause proportions below a continuing day size (12 h) and ranging night time lengths in photoperiods starting from 16 to 84 h at 16°C. Within the northernmost strains (above 55°N), almost all females entered diapause below all photoperiods and about half of them even in steady darkness, whereas the females of the southern strains confirmed excessive diapause proportions solely within the circadian 24 h photoperiod.
Important correlation between the strains’ imply diapause proportions in ≥ 24 h photoperiods and important day size (CDL; half of the females enter diapause) suggests at the least partial causal connection between the traits. Apparently, females of the northern strains entered diapause even in ≤ 24 h photoperiods, the place the night time size was shorter than their important night time size (24 h – CDL), however the place the females skilled a better variety of Gentle:Darkish cycles than in 24 h photoperiods.
NH experiments, carried out on the management and choice strains in our earlier choice experiment, and accomplished right here, gave comparable outcomes and confirmed that choice for shorter, southern-type CDL decreases feminine diapausing fee in non-circadian photoperiods. Total, our research exhibits that D. montana females measure night time size quantitatively, that the photoperiodic counter could play a distinguished however barely totally different position in further quick and further lengthy photoperiods and that northern strains present excessive stability towards perturbations within the photoperiod size and within the presence of LD cycles. These options are finest defined by the quantitative variations of the damped exterior coincidence mannequin.
Natural Zeitgebers Under Temperate Conditions Cannot Compensate for the Loss of a Functional Circadian Clock in Timing of a Vital Behavior in Drosophila

Interaction between intercourse willpower cascade and main signaling pathways throughout Drosophila eye improvement: Views for future analysis

Understanding molecular mechanisms of sexually dimorphic organ progress is a elementary downside of developmental biology. Current quantitative research confirmed that the Drosophila compound eye is a handy mannequin to review the willpower of the ultimate organ measurement. In Drosophila, females have bigger eyes than males and that is evident even after correction for the bigger physique measurement. Furthermore, feminine eyes embody extra ommatidia (photosensitive items) than male eyes and this distinction is specified on the third larval instar within the eye primordia referred to as eye imaginal discs. This will likely end in totally different visible capabilities between the 2 sexes and have behavioral penalties.
Regardless of rising proof on the genetic bases of eye measurement variation between totally different Drosophila species and strains, mechanisms accountable for within-species sexual dimorphism nonetheless stay elusive. Right here, we focus on a presumptive crosstalk between the intercourse willpower cascade and main signaling pathways throughout dimorphic eye improvement. Male- and female-specific isoforms of Doublesex (Dsx) protein are identified to regulate sex-specific differentiation within the somatic tissues. Nonetheless, no information on Dsx perform throughout eye disc progress and patterning are presently accessible.
Remarkably, Intercourse deadly (Sxl), the intercourse willpower change protein, was proven to straight have an effect on Hedgehog (Hh) and Notch (N) signaling within the Drosophila wing disc. The similarity of signaling pathways concerned within the wing and eye disc progress means that Sxl is perhaps built-in into regulation of eye improvement. Dsx position within the eye disc requires additional investigation. We focus on presently accessible information on sex-biased gene expression within the Drosophila eye and spotlight views for future research.

DNA polymerase theta suppresses mitotic crossing over

Polymerase theta-mediated finish becoming a member of (TMEJ) is a chromosome break restore pathway that is ready to rescue the lethality related to the lack of proteins concerned in early steps in homologous recombination (e.g., BRCA1/2). That is because of the capacity of polymerase theta (Pol θ) to make use of resected, 3′ single stranded DNA tails to restore chromosome breaks. These resected DNA tails are additionally the beginning substrate for homologous recombination. Nonetheless, it stays unknown if TMEJ can compensate for the lack of proteins concerned in additional downstream steps throughout homologous recombination. Right here we present that the Holliday junction resolvases SLX4 and GEN1 are required for viability within the absence of Pol θ in Drosophila melanogaster, and lack of all three proteins ends in excessive ranges of apoptosis.
Flies poor in Pol θ and SLX4 are extraordinarily delicate to DNA damaging brokers, and mammalian cells require both Pol θ or SLX4 to outlive. Our outcomes recommend that TMEJ and Holliday junction formation/decision share a standard DNA substrate, seemingly a homologous recombination intermediate, that when left unrepaired results in cell demise. One main consequence of Holliday junction decision by SLX4 and GEN1 is cancer-causing lack of heterozygosity as a consequence of mitotic crossing over. We measured mitotic crossovers in flies after a Cas9-induced chromosome break, and noticed that this mutagenic type of restore is elevated within the absence of Pol θ.

Monoclonal COPB Antibody (monoclonal) (M08), Clone: 3E11
APR15551G 0.1mg
EUR 484
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Monoclonal FBL Antibody (monoclonal) (M09), Clone: 3E11
APR15927G 0.1mg
EUR 484
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Monoclonal COPl Antibody (monoclonal) (M01), Clone: 3E11
AMM03405G 0.1mg
EUR 484
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Monoclonal HERPUD1 Antibody (monoclonal) (M01), Clone: 3E11
AMM03617G 0.1mg
EUR 484
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Monoclonal ID3 Antibody (monoclonal) (M02), Clone: 3E11
AMM03649G 0.1mg
EUR 484
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Monoclonal LY6H Antibody (monoclonal) (M01), Clone: 3E11
AMM03754G 0.1mg
EUR 484
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Monoclonal MAP2K5 Antibody (monoclonal) (M11), Clone: 3E11
AMM03762G 0.1mg
EUR 484
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Monoclonal SMARCB1 Antibody (monoclonal) (M01), Clone: 3E11
AMM04112G 0.1mg
EUR 484
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Monoclonal HIP1R Antibody (monoclonal) (M01), Clone: 3E11
APR12375G 0.05mg
EUR 484
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Monoclonal TCF4 Antibody (monoclonal) (M01), Clone: 3E11
APR14413G 0.1mg
EUR 484
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Monoclonal PDLIM5 Antibody (monoclonal) (M01), Clone: 3E11-F6
APR12791G 0.1mg
EUR 484
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Anti Mummichog Vitellogenin Monoclonal Antibody (Clone No. 3E11)
KH005
EUR 544
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anti-HDAC3 (3E11)
LF-MA10133 100 ug
EUR 363
Description: Mouse monoclonal to HDAC3

Anti-Osteopontin (3E11)
YF-MA15581 100 ug
EUR 363
Description: Mouse monoclonal to Osteopontin

Anti-TCF2 (3E11)
YF-MA15765 100 ug
EUR 363
Description: Mouse monoclonal to TCF2

Anti-KLF10 (3E11)
YF-MA15849 100 ug
EUR 363
Description: Mouse monoclonal to KLF10

Anti-ZNF187 (3E11)
YF-MA16192 100 ug
EUR 363
Description: Mouse monoclonal to ZNF187

Anti-CER1 (3E11)
YF-MA16795 100 ug
EUR 363
Description: Mouse monoclonal to CER1

Anti-TIP30 (3E11)
YF-MA17378 100 ug
EUR 363
Description: Mouse monoclonal to TIP30

Anti-CCRK (3E11)
YF-MA17926 100 ug
EUR 363
Description: Mouse monoclonal to CCRK

Anti-BTBD1 (3E11)
YF-MA18595 100 ug
EUR 363
Description: Mouse monoclonal to BTBD1

Anti-ALS2CR2 (3E11)
YF-MA18781 100 ug
EUR 363
Description: Mouse monoclonal to ALS2CR2

Anti-SPG (3E11)
YF-MA18829 50 ug
EUR 363
Description: Mouse monoclonal to SPG

Anti-cvHSP (3E11)
YF-MA11450 100 ug
EUR 363
Description: Mouse monoclonal to cvHSP

Anti-AKT1 (3E11)
YF-MA11876 100 ug
EUR 363
Description: Mouse monoclonal to AKT1

Anti-OSGIN2 (3E11)
YF-MA12209 100 ug
EUR 363
Description: Mouse monoclonal to OSGIN2

Anti-FMRP (3E11)
YF-MA13101 100 ug
EUR 363
Description: Mouse monoclonal to FMRP

Anti-MCM3 (3E11)
YF-MA14152 100 ug
EUR 363
Description: Mouse monoclonal to MCM3

Anti-NHLH2 (3E11)
YF-MA14458 100 ug
EUR 363
Description: Mouse monoclonal to NHLH2

Anti-POMC (3E11)
YF-MA14807 100 ug
EUR 363
Description: Mouse monoclonal to POMC

Anti-RPL23A (3E11)
YF-MA15244 100 ug
EUR 363
Description: Mouse monoclonal to RPL23A

Anti-Psoriasin (3E11)
YF-MA15314 50 ug
EUR 363
Description: Mouse monoclonal to Psoriasin

Anti-Psoriasin (3E11)
YF-MA15315 200 ul
EUR 363
Description: Mouse monoclonal to Psoriasin

Anti-MRPS36 (3E11)
YF-MA19657 100 ug
EUR 363
Description: Mouse monoclonal to MRPS36

Anti-MPO (3E11)
YF-MA20367 100 ug
EUR 363
Description: Mouse monoclonal to MPO

Anti-ARFGEF1 (3E11)
YF-MA20498 100 ug
EUR 363
Description: Mouse monoclonal to ARFGEF1

Anti-Twist (3E11)
YF-MA10977 100 ug
EUR 363
Description: Mouse monoclonal to Twist

Monoclonal Ku (p70/p80)Mouse Monoclonal Antibody [Clone KU729], Clone: KU729
AMM00210G 0.5ml
EUR 484
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Monoclonal mouse Lplunc1 Antibody, Clone: 4H2
APR08492G 0.1ml
EUR 528
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Monoclonal mouse Lplunc1 Antibody, Clone: 1F11E3
APR08493G 0.1ml
EUR 528
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Monoclonal mouse Splunc2 Antibody, Clone: 1F12
APR07136G 0.1ml
EUR 528
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Monoclonal Mouse Bmi1 Antibody, Clone: 353CT22.4.4
AMM02383G 0.1ml
EUR 484
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Monoclonal S100A8 Antibody (Clone IMG48M7C7), Clone: Clone IMG48M7C7
AMM00015G 0.1mg
EUR 528
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Monoclonal PDGFR Antibody (Clone # 275CT1), Clone: Clone # 275CT1
AMM00020G 0.05ml
EUR 484
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Monoclonal NGFR Antibody (Clone # 8G3G10), Clone: Clone # 8G3G10
AMM06686G 0.1ml
EUR 484
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Monoclonal CD28 FITC Monoclonal Antibody (Clone CD28.2), Clone: CD28.2
AMM00025G 0.05mg
EUR 396
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Monoclonal CD11c FITC Monoclonal Antibody (Clone 3.9), Clone: 3.9
APR15331G 50 tests
EUR 484
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anti-Progesteron Receptor (3E11)
LF-MA10230 100 ug
EUR 363
Description: Mouse monoclonal to Progesteron Receptor

Anti-PDLIM5 (3E11-F6)
YF-MA11302 100 ug
EUR 363
Description: Mouse monoclonal to PDLIM5

Anti-IkB beta (3E11)
YF-MA14442 100 ug
EUR 363
Description: Mouse monoclonal to IkB beta

Anti-ORC2 (3E11-1G5)
YF-MA10652 100 ug
EUR 363
Description: Mouse monoclonal to ORC2

Monoclonal FTL Antibody (monoclonal), Clone: 4G7
AMM04622G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human FTL (monoclonal). The antibodies are raised in Mouse and are from clone 4G7. This antibody is applicable in WB, E

Monoclonal CST3 Antibody (monoclonal), Clone: 1H4
AMM03425G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human CST3 (monoclonal). The antibodies are raised in Mouse and are from clone 1H4. This antibody is applicable in WB

Monoclonal TNFSF18 Antibody (monoclonal), Clone: 2E11
AMM04221G 0.1mg
EUR 484
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Monoclonal FADD Antibody (Clone T1B), Clone: T1B
AMM00001G 0.1mg
EUR 528
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Monoclonal p53 Antibody (Clone C6A5), Clone: C6A5
AMM00003G 0.1mg
EUR 528
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Monoclonal IkBalpha Antibody (Clone 6A055), Clone: 6A055
AMM00004G 0.1mg
EUR 528
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Monoclonal ROCK1 Antibody (Clone 12M03), Clone: 12M03
AMM00007G 0.1mg
EUR 528
Description: A Monoclonal antibody against Human ROCK1 (Clone 12M03). The antibodies are raised in Mouse and are from clone 12M03. This antibody is applicable in WB

Monoclonal CD3 Antibody (Clone OKT3), Clone: OKT3
AMM00016G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human CD3 (Clone OKT3). The antibodies are raised in Mouse and are from clone OKT3. This antibody is applicable in FC

Monoclonal PODXL Antibody [Clone 2A4], Clone: 2A4
AMM00040G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human PODXL [Clone 2A4]. The antibodies are raised in Mouse and are from clone 2A4. This antibody is applicable in WB, IHC and IF, FC, IP

Monoclonal PODXL Antibody [Clone 4F10], Clone: 4F10
AMM00051G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human PODXL [Clone 4F10]. The antibodies are raised in Mouse and are from clone 4F10. This antibody is applicable in WB, IHC and IF, FC, IP

Monoclonal CD20 Antibody [Clone B9E9], Clone: B9E9
AMM00065G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human CD20 [Clone B9E9]. The antibodies are raised in Mouse and are from clone B9E9. This antibody is applicable in FC

Monoclonal CD20 Antibody [Clone B9E9], Clone: B9E9
AMM00066G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human CD20 [Clone B9E9]. The antibodies are raised in Mouse and are from clone B9E9. This antibody is applicable in FC

Monoclonal C4d Antibody [Clone C4D203], Clone: C4D203
AMM00080G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human C4d [Clone C4D203]. The antibodies are raised in Mouse and are from clone C4D203. This antibody is applicable in IF

Monoclonal C4d Antibody [Clone C4D205], Clone: C4D205
AMM00082G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human C4d [Clone C4D205]. The antibodies are raised in Mouse and are from clone C4D205. This antibody is applicable in IF

Monoclonal Vimentin Antibody [Clone LN6], Clone: LN6
AMM00156G 0.1mg
EUR 484
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Monoclonal C4d Antibody [Clone TDM16], Clone: TDM16
AMM00188G 0.1mg
EUR 484
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Monoclonal CD33 Antibody [Clone WM53], Clone: WM53
AMM00203G 0.1mg
EUR 484
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Monoclonal CD33 Antibody [Clone WM53], Clone: WM53
AMM00204G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human CD33 [Clone WM53]. The antibodies are raised in Mouse and are from clone WM53. This antibody is applicable in FC

Monoclonal SLC13A5 Antibody (clone 2G4), Clone: 2G4
APR09978G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human SLC13A5 (clone 2G4). The antibodies are raised in Mouse and are from clone 2G4. This antibody is applicable in WB and IHC-P, E

Monoclonal SLC22A1 Antibody (clone 2C5), Clone: 2C5
APR10013G 0.05ml
EUR 484
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Monoclonal SMAD3 Antibody (clone 2C12), Clone: 2C12
APR10161G 0.05mg
EUR 528
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Monoclonal SMAD3 Antibody (clone AF9F7), Clone: AF9F7
APR10162G 0.05ml
EUR 484
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Monoclonal SOCS3 Antibody (clone SO1), Clone: SO1
APR10171G 0.05mg
EUR 484
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Monoclonal SOD3 Antibody (clone 1H12), Clone: 1H12
APR10200G 0.05ml
EUR 484
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Monoclonal STAT1 Antibody (clone AT1FA), Clone: AT1FA
APR10265G 0.05ml
EUR 484
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Monoclonal STAT1 Antibody (clone SM1), Clone: SM1
APR10266G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human STAT1 (clone SM1). The antibodies are raised in Mouse and are from clone SM1. This antibody is applicable in WB and IHC-P, IP

Monoclonal STAT5A Antibody (clone 9F7), Clone: 9F7
APR10279G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human STAT5A (clone 9F7). The antibodies are raised in Mouse and are from clone 9F7. This antibody is applicable in WB and IHC-P, IF, Flo

Monoclonal STAT5B Antibody (clone 2D1), Clone: 2D1
APR10281G 0.05mg
EUR 528
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Monoclonal STAT5B Antibody (clone 5D6), Clone: 5D6
APR10282G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human STAT5B (clone 5D6). The antibodies are raised in Mouse and are from clone 5D6. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal TDO2 Antibody (clone 4G2), Clone: 4G2
APR10390G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human TDO2 (clone 4G2). The antibodies are raised in Mouse and are from clone 4G2. This antibody is applicable in WB and IHC-P

Monoclonal TOM20 Antibody (clone 4F3), Clone: 4F3
APR10504G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human TOM20 (clone 4F3). The antibodies are raised in Mouse and are from clone 4F3. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal UQCRC1 Antibody (clone 1G6), Clone: 1G6
APR10666G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human UQCRC1 (clone 1G6). The antibodies are raised in Mouse and are from clone 1G6. This antibody is applicable in WB and IHC-P, Flo

Monoclonal VCP Antibody (clone 4A8), Clone: 4A8
APR10681G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human VCP (clone 4A8). The antibodies are raised in Mouse and are from clone 4A8. This antibody is applicable in WB and IHC-P, E

Monoclonal VCP Antibody (clone 4G9), Clone: 4G9
APR10682G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human VCP (clone 4G9). The antibodies are raised in Mouse and are from clone 4G9. This antibody is applicable in WB and IHC-P, IF, ICC, IP

Monoclonal VLDLR Antibody (clone 1H10), Clone: 1H10
APR10743G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human VLDLR (clone 1H10). The antibodies are raised in Mouse and are from clone 1H10. This antibody is applicable in WB and IHC-P, E

Monoclonal VNN1 Antibody (clone 4E11), Clone: 4E11
APR10746G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human VNN1 (clone 4E11). The antibodies are raised in Mouse and are from clone 4E11. This antibody is applicable in IHC-P, E

Monoclonal BPIFB1 Antibody (clone 2A5), Clone: 2A5
APR11011G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human BPIFB1 (clone 2A5). The antibodies are raised in Mouse and are from clone 2A5. This antibody is applicable in WB and IHC-P, IF, ICC, E, Flo

Monoclonal GMEB1 Antibody (clone 2A8), Clone: 2A8
APR11097G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human GMEB1 (clone 2A8). The antibodies are raised in Mouse and are from clone 2A8. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal STAT3 Antibody (clone 7G3H4), Clone: 7G3H4
APR11201G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human STAT3 (clone 7G3H4). The antibodies are raised in Mouse and are from clone 7G3H4. This antibody is applicable in WB and IHC-P, E

Monoclonal TLR4 Antibody (clone 3B6), Clone: 3B6
APR11219G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human TLR4 (clone 3B6). The antibodies are raised in Mouse and are from clone 3B6. This antibody is applicable in WB and IHC-P, E

Monoclonal CRIM1 Antibody (clone 6E4), Clone: 6E4
APR11670G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human CRIM1 (clone 6E4). The antibodies are raised in Mouse and are from clone 6E4. This antibody is applicable in WB and IHC-P, E

Monoclonal DLX2 Antibody (clone 2E12), Clone: 2E12
APR11769G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human DLX2 (clone 2E12). The antibodies are raised in Mouse and are from clone 2E12. This antibody is applicable in WB and IHC-P, E

Monoclonal DLX2 Antibody (clone 4B9), Clone: 4B9
APR11770G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human DLX2 (clone 4B9). The antibodies are raised in Mouse and are from clone 4B9. This antibody is applicable in WB and IHC-P, E

Monoclonal HIBCH Antibody (clone 5C5), Clone: 5C5
APR07744G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human HIBCH (clone 5C5). The antibodies are raised in Mouse and are from clone 5C5. This antibody is applicable in WB and IHC-P, IF, Flo

Monoclonal HSF1 Antibody (clone J7F9), Clone: J7F9
APR07809G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human HSF1 (clone J7F9). The antibodies are raised in Mouse and are from clone J7F9. This antibody is applicable in WB and IHC-P, E

Monoclonal HSF1 Antibody (clone 10H8), Clone: 10H8
APR07828G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human HSF1 (clone 10H8). The antibodies are raised in Rat and are from clone 10H8. This antibody is applicable in WB and IHC-P, IF, ICC, E, IP, GS

Monoclonal IDH2 Antibody (clone 5F11), Clone: 5F11
APR07925G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human IDH2 (clone 5F11). The antibodies are raised in Mouse and are from clone 5F11. This antibody is applicable in WB and IHC-P, E

Monoclonal Insulin Antibody (clone D3E7), Clone: D3E7
APR08006G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human Insulin (clone D3E7). The antibodies are raised in Mouse and are from clone D3E7. This antibody is applicable in IHC-P, E, IHC-Fr

Monoclonal Insulin Antibody (clone E2E3), Clone: E2E3
APR08007G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human Insulin (clone E2E3). The antibodies are raised in Mouse and are from clone E2E3. This antibody is applicable in IHC-P, E, IHC-Fr

Monoclonal Insulin Antibody (clone INS04), Clone: INS04
APR08008G 0.1ml
EUR 484
Description: A Monoclonal antibody against Human Insulin (clone INS04). The antibodies are raised in Mouse and are from clone INS04. This antibody is applicable in IHC-P

Monoclonal MDH1 Antibody (clone 1D2), Clone: 1D2
APR08398G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human MDH1 (clone 1D2). The antibodies are raised in Mouse and are from clone 1D2. This antibody is applicable in WB and IHC-P, E

Monoclonal MVK Antibody (clone AT14F6), Clone: AT14F6
APR08580G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human MVK (clone AT14F6). The antibodies are raised in Mouse and are from clone AT14F6. This antibody is applicable in WB and IHC-P, E

Monoclonal NANS Antibody (clone AT1G6), Clone: AT1G6
APR08593G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human NANS (clone AT1G6). The antibodies are raised in Mouse and are from clone AT1G6. This antibody is applicable in WB and IHC-P, E

Monoclonal NEUROD1 Antibody (clone 3D11), Clone: 3D11
APR08714G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human NEUROD1 (clone 3D11). The antibodies are raised in Mouse and are from clone 3D11. This antibody is applicable in WB and IHC-P, E

Monoclonal NEUROD1 Antibody (clone 3H8), Clone: 3H8
APR08715G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human NEUROD1 (clone 3H8). The antibodies are raised in Mouse and are from clone 3H8. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal OAT Antibody (clone AT23A2), Clone: AT23A2
APR08879G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human OAT (clone AT23A2). The antibodies are raised in Mouse and are from clone AT23A2. This antibody is applicable in IHC-P

Monoclonal PARP Antibody (Clone 10H), Clone: 10H
APR08930G 0.1mg
EUR 528
Description: A Monoclonal antibody against Human PARP (Clone 10H). The antibodies are raised in Mouse and are from clone 10H. This antibody is applicable in WB, ICC, E, IP

Monoclonal PARP Antibody (Clone 7A10), Clone: 7A10
APR08931G 0.1ml
EUR 528
Description: A Monoclonal antibody against Human PARP (Clone 7A10). The antibodies are raised in Mouse and are from clone 7A10. This antibody is applicable in WB, FC, ICC

Monoclonal PARP1 Antibody (clone A6.4.12), Clone: A6.4.12
APR08939G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human PARP1 (clone A6.4.12). The antibodies are raised in Mouse and are from clone A6.4.12. This antibody is applicable in WB and IHC-P, E, IP, IHC-Fr

Monoclonal PAWR Antibody (clone 3G9H7,4H12E9), Clone: 3G9H7,4H12E9
APR08945G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human PAWR (clone 3G9H7,4H12E9). The antibodies are raised in Mouse and are from clone 3G9H7,4H12E9. This antibody is applicable in WB and IHC-P, E

Monoclonal PCSK1 Antibody (clone 3D2), Clone: 3D2
APR08955G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human PCSK1 (clone 3D2). The antibodies are raised in Mouse and are from clone 3D2. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal PDK2 Antibody (clone 2G1), Clone: 2G1
APR09004G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human PDK2 (clone 2G1). The antibodies are raised in Mouse and are from clone 2G1. This antibody is applicable in WB and IHC-P, E

Monoclonal PDK2 Antibody (clone 5F8), Clone: 5F8
APR09005G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human PDK2 (clone 5F8). The antibodies are raised in Mouse and are from clone 5F8. This antibody is applicable in WB and IHC-P, E

Monoclonal PDZK1 Antibody (clone AT1A2), Clone: AT1A2
APR09030G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human PDZK1 (clone AT1A2). The antibodies are raised in Mouse and are from clone AT1A2. This antibody is applicable in WB and IHC-P, E

Monoclonal PGD Antibody (clone 2A5), Clone: 2A5
APR09072G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human PGD (clone 2A5). The antibodies are raised in Mouse and are from clone 2A5. This antibody is applicable in WB and IHC-P, IF

Monoclonal CD34 Antibody (clone EP88), Clone: EP88
AMR03190G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human CD34 (clone EP88). The antibodies are raised in Rabbit and are from clone EP88. This antibody is applicable in IHC-P, IHC-Fr

Monoclonal PLCG1 Antibody (clone 2B1), Clone: 2B1
AMR09352G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human PLCG1 (clone 2B1). The antibodies are raised in Mouse and are from clone 2B1. This antibody is applicable in WB and IHC-P, IP

Monoclonal PNMT Antibody (clone AT1C11), Clone: AT1C11
AMR09408G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human PNMT (clone AT1C11). The antibodies are raised in Mouse and are from clone AT1C11. This antibody is applicable in WB and IHC-P, E

Monoclonal PNPO Antibody (clone AT2C7), Clone: AT2C7
AMR09416G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human PNPO (clone AT2C7). The antibodies are raised in Mouse and are from clone AT2C7. This antibody is applicable in WB and IHC-P, E

Monoclonal PON3 Antibody (clone 5G11), Clone: 5G11
AMR09422G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human PON3 (clone 5G11). The antibodies are raised in Mouse and are from clone 5G11. This antibody is applicable in WB and IHC-P

Monoclonal PTGES3 Antibody (clone JJ6), Clone: JJ6
AMR09608G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human PTGES3 (clone JJ6). The antibodies are raised in Mouse and are from clone JJ6. This antibody is applicable in WB and IHC-P, E, IP

Monoclonal PTP1B Antibody (Clone 107AT531), Clone: 107AT531
AMR09648G 0.1mg
EUR 528
Description: A Monoclonal antibody against Human PTP1B (Clone 107AT531). The antibodies are raised in Mouse and are from clone 107AT531. This antibody is applicable in WB, E

Monoclonal PYGM Antibody (clone 2C4), Clone: 2C4
AMR09675G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human PYGM (clone 2C4). The antibodies are raised in Mouse and are from clone 2C4. This antibody is applicable in WB and IHC-P, E

Monoclonal REG1A Antibody (clone 1A4), Clone: 1A4
AMR09710G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human REG1A (clone 1A4). The antibodies are raised in Mouse and are from clone 1A4. This antibody is applicable in IHC-P, IF, E

Monoclonal SDSL Antibody (clone M2), Clone: M2
AMR09854G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human SDSL (clone M2). The antibodies are raised in Mouse and are from clone M2. This antibody is applicable in WB and IHC-P, E

Monoclonal CD34 Antibody (clone MEC14.7), Clone: MEC14.7
AMRa00010G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human CD34 (clone MEC14.7). The antibodies are raised in Rat and are from clone MEC14.7. This antibody is applicable in IHC-P, IP, Flo

Monoclonal CD44 Antibody (clone IM7), Clone: IM7
AMRa00013G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human CD44 (clone IM7). The antibodies are raised in Rat and are from clone IM7. This antibody is applicable in WB and IHC-P, ICC, IP, IHC-Fr, Flo

Monoclonal EBI3 Antibody (clone DNT27), Clone: DNT27
AMRa00014G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human EBI3 (clone DNT27). The antibodies are raised in Rat and are from clone DNT27. This antibody is applicable in WB and IHC-P

Monoclonal NDRG4 Antibody (clone 2G3), Clone: 2G3
AMM06585G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human NDRG4 (clone 2G3). The antibodies are raised in Mouse and are from clone 2G3. This antibody is applicable in WB and IHC-P, E

Monoclonal Neuroserpin Antibody (clone 1D10), Clone: 1D10
AMM06649G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human Neuroserpin (clone 1D10). The antibodies are raised in Mouse and are from clone 1D10. This antibody is applicable in WB and IHC-P, E

Monoclonal NR1D1 Antibody (clone 4F6), Clone: 4F6
AMM06804G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human NR1D1 (clone 4F6). The antibodies are raised in Mouse and are from clone 4F6. This antibody is applicable in WB and IHC-P, IF, E, RNAi

Monoclonal OLIG2 Antibody (clone 3C9), Clone: 3C9
AMM06897G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human OLIG2 (clone 3C9). The antibodies are raised in Mouse and are from clone 3C9. This antibody is applicable in WB and IHC-P, E

Monoclonal EDEM2 Antibody (clone 2E4), Clone: 2E4
AMM07004G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human EDEM2 (clone 2E4). The antibodies are raised in Mouse and are from clone 2E4. This antibody is applicable in WB and IHC-P, E

Monoclonal PDE9A Antibody (clone 1E1), Clone: 1E1
AMM07065G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human PDE9A (clone 1E1). The antibodies are raised in Mouse and are from clone 1E1. This antibody is applicable in WB and IHC-P, E

Monoclonal PGRMC2 Antibody (clone 3C11), Clone: 3C11
AMM07132G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human PGRMC2 (clone 3C11). The antibodies are raised in Mouse and are from clone 3C11. This antibody is applicable in WB and IHC-P, E

Monoclonal RAPGEF6 Antibody (clone 2C5), Clone: 2C5
AMM07531G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human RAPGEF6 (clone 2C5). The antibodies are raised in Mouse and are from clone 2C5. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal SOCS1 Antibody (clone 4H1), Clone: 4H1
AMM07943G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human SOCS1 (clone 4H1). The antibodies are raised in Mouse and are from clone 4H1. This antibody is applicable in WB and IHC-P

Monoclonal STK16 Antibody (clone M2), Clone: M2
AMM08020G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human STK16 (clone M2). The antibodies are raised in Mouse and are from clone M2. This antibody is applicable in WB and IHC-P, E, RNAi

Monoclonal STK33 Antibody (clone 3F10), Clone: 3F10
AMM08027G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human STK33 (clone 3F10). The antibodies are raised in Mouse and are from clone 3F10. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal TNNI2 Antibody (clone 11E6), Clone: 11E6
AMM08268G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human TNNI2 (clone 11E6). The antibodies are raised in Mouse and are from clone 11E6. This antibody is applicable in WB and IHC-P, E

Monoclonal TNNI2 Antibody (clone 2F12G2), Clone: 2F12G2
AMM08269G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human TNNI2 (clone 2F12G2). The antibodies are raised in Mouse and are from clone 2F12G2. This antibody is applicable in WB and IHC-P, IF, ICC, E, Flo

Monoclonal TTC1 Antibody (clone 4E3), Clone: 4E3
AMM08362G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human TTC1 (clone 4E3). The antibodies are raised in Mouse and are from clone 4E3. This antibody is applicable in WB and IHC-P, E

Monoclonal TUBB2B Antibody (clone AT5B3), Clone: AT5B3
AMM08382G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human TUBB2B (clone AT5B3). The antibodies are raised in Mouse and are from clone AT5B3. This antibody is applicable in IHC-P

Monoclonal VASP Antibody (clone 4D6), Clone: 4D6
AMM08458G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human VASP (clone 4D6). The antibodies are raised in Mouse and are from clone 4D6. This antibody is applicable in WB and IHC-P, IF, Flo

Monoclonal FOXA2 Antibody (clone 1C7), Clone: 1C7
AMM04590G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human FOXA2 (clone 1C7). The antibodies are raised in Mouse and are from clone 1C7. This antibody is applicable in WB and IHC-P, IF, E, IP

Monoclonal G6PD Antibody (clone AT2F6), Clone: AT2F6
AMM04645G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human G6PD (clone AT2F6). The antibodies are raised in Mouse and are from clone AT2F6. This antibody is applicable in WB and IHC-P, E

Monoclonal GALT Antibody (clone 4C11), Clone: 4C11
AMM04683G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human GALT (clone 4C11). The antibodies are raised in Mouse and are from clone 4C11. This antibody is applicable in WB and IHC-P, E

Monoclonal GAPDH Antibody (clone 1D4), Clone: 1D4
AMM04700G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human GAPDH (clone 1D4). The antibodies are raised in Mouse and are from clone 1D4. This antibody is applicable in WB and IHC-P, IF

Monoclonal GAPDH Antibody (clone 4G5), Clone: 4G5
AMM04701G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human GAPDH (clone 4G5). The antibodies are raised in Mouse and are from clone 4G5. This antibody is applicable in WB and IHC-P, IF, E, IP, IHC-Fr

Monoclonal GAPDH Antibody (clone 4G5), Clone: 4G5
AMM04702G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human GAPDH (clone 4G5). The antibodies are raised in Mouse and are from clone 4G5. This antibody is applicable in WB and IHC-P, IF, E, IP

Monoclonal GAPDH Antibody (clone 6C5), Clone: 6C5
AMM04703G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human GAPDH (clone 6C5). The antibodies are raised in Mouse and are from clone 6C5. This antibody is applicable in WB and IHC-P, IF, E, IP, IHC-Fr

Monoclonal GAPDH Antibody (clone B903M), Clone: B903M
AMM04704G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human GAPDH (clone B903M). The antibodies are raised in Mouse and are from clone B903M. This antibody is applicable in WB and IHC-P, ICC, E

Monoclonal GOT2 Antibody (clone 3E9), Clone: 3E9
AMM05170G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human GOT2 (clone 3E9). The antibodies are raised in Mouse and are from clone 3E9. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal GPI Antibody (clone 1B7D7), Clone: 1B7D7
AMM05182G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human GPI (clone 1B7D7). The antibodies are raised in Mouse and are from clone 1B7D7. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal GPI Antibody (clone 4B11), Clone: 4B11
AMM05183G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human GPI (clone 4B11). The antibodies are raised in Mouse and are from clone 4B11. This antibody is applicable in WB and IHC-P, IF

Monoclonal GPX7 Antibody (clone 2704), Clone: 2704
AMM05213G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human GPX7 (clone 2704). The antibodies are raised in Mouse and are from clone 2704. This antibody is applicable in WB and IHC-P

Monoclonal GSTA1 Antibody (clone 2F7), Clone: 2F7
AMM05231G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human GSTA1 (clone 2F7). The antibodies are raised in Mouse and are from clone 2F7. This antibody is applicable in WB and IHC-P, E

Monoclonal GSTA3 Antibody (clone 1F11), Clone: 1F11
AMM05234G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human GSTA3 (clone 1F11). The antibodies are raised in Mouse and are from clone 1F11. This antibody is applicable in WB and IHC-P, E

Monoclonal GSTM2 Antibody (clone 1E10), Clone: 1E10
AMM05250G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human GSTM2 (clone 1E10). The antibodies are raised in Mouse and are from clone 1E10. This antibody is applicable in WB and IHC-P, E

Monoclonal HDAC3 Antibody (clone 7G6C5), Clone: 7G6C5
AMM05320G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human HDAC3 (clone 7G6C5). The antibodies are raised in Mouse and are from clone 7G6C5. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal CD80 Antibody (clone 2A2), Clone: 2A2
AMM05353G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human CD80 (clone 2A2). The antibodies are raised in Mouse and are from clone 2A2. This antibody is applicable in IHC-P, IF, E

Monoclonal CD86 Antibody [Clone BU63], Clone: BU63
AMM05354G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human CD86 [Clone BU63]. The antibodies are raised in Mouse and are from clone BU63. This antibody is applicable in WB, IP

Monoclonal CD86 Antibody [Clone BU63], Clone: BU63
AMM05355G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human CD86 [Clone BU63]. The antibodies are raised in Mouse and are from clone BU63. This antibody is applicable in FC

Monoclonal TSG101 Antibody (clone 5B7), Clone: 5B7
AMM05442G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human TSG101 (clone 5B7). The antibodies are raised in Mouse and are from clone 5B7. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal CACNA2D2 Antibody (clone 3A4), Clone: 3A4
AMM05669G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human CACNA2D2 (clone 3A4). The antibodies are raised in Mouse and are from clone 3A4. This antibody is applicable in WB and IHC-P, E
This demonstrates that TMEJ can perform upstream of the Vacation junction resolvases to guard cells from lack of heterozygosity. Our work argues that Pol θ can thus compensate for the lack of the Holliday junction resolvases by utilizing homologous recombination intermediates, suppressing mitotic crossing over and preserving the genomic stability of cells.
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