Natural Zeitgebers Under Temperate Conditions Cannot Compensate for the Loss of a Functional Circadian Clock in Timing of a Vital Behavior in Drosophila

Natural Zeitgebers Under Temperate Conditions Cannot Compensate for the Loss of a Functional Circadian Clock in Timing of a Vital Behavior in Drosophila

Natural Zeitgebers Under Temperate Conditions Cannot Compensate for the Loss of a Functional Circadian Clock in Timing of a Vital Behavior in Drosophila

The adaptive significance of adjusting behavioral actions to the best time of the day appears apparent. Laboratory research implicated an essential position of circadian clocks in behavioral timing and rhythmicity. But, latest research on clock-mutant animals questioned this significance below extra naturalistic settings, as numerous clock mutants confirmed almost regular diel exercise rhythms below seminatural zeitgeber circumstances.
We right here report proof that correct timing of eclosion, a significant habits of the fruit fly Drosophila melanogaster, requires a purposeful molecular clock below quasi-natural circumstances. In distinction to wild-type flies, interval01 mutants with a faulty molecular clock confirmed impaired rhythmicity and gating in a temperate setting even within the presence of a full complement of abiotic zeitgebers. Though interval01 mutants nonetheless eclosed throughout a sure time window in the course of the day, this time window was a lot broader and loosely outlined, and rhythmicity was decrease or misplaced as categorized by numerous statistical measures. Furthermore, peak eclosion time turned extra inclined to variable day-to-day modifications of sunshine.
In distinction, flies with impaired peptidergic interclock signaling (Pdf01 and han5304 PDF receptor mutants) eclosed largely rhythmically with regular gate sizes, much like wild-type controls. Our outcomes recommend that the presence of pure zeitgebers isn’t adequate, and a purposeful molecular clock is required to induce steady temporal eclosion patterns in flies below temperate circumstances with appreciable day-to-day variation in gentle depth and temperature. Temperate zeitgebers are, nonetheless, adequate to functionally rescue a lack of PDF-mediated clock-internal and -output signaling.

Nanda-Hamner Curves Present Large Latitudinal Variation however No Circadian Elements in Drosophila Montana Photoperiodism

Insect species with a large distribution provide an important alternative to hint latitudinal variation within the photoperiodic regulation of traits essential in copy and stress tolerances. We measured this variation within the photoperiodic time-measuring system underlying reproductive diapause in Drosophila montana, utilizing a Nanda-Hamner (NH) protocol. Not one of the research strains confirmed diel rhythmicity in feminine diapause proportions below a continuing day size (12 h) and ranging night time lengths in photoperiods starting from 16 to 84 h at 16°C. Within the northernmost strains (above 55°N), almost all females entered diapause below all photoperiods and about half of them even in steady darkness, whereas the females of the southern strains confirmed excessive diapause proportions solely within the circadian 24 h photoperiod.
Important correlation between the strains’ imply diapause proportions in ≥ 24 h photoperiods and important day size (CDL; half of the females enter diapause) suggests at the least partial causal connection between the traits. Apparently, females of the northern strains entered diapause even in ≤ 24 h photoperiods, the place the night time size was shorter than their important night time size (24 h – CDL), however the place the females skilled a better variety of Gentle:Darkish cycles than in 24 h photoperiods.
NH experiments, carried out on the management and choice strains in our earlier choice experiment, and accomplished right here, gave comparable outcomes and confirmed that choice for shorter, southern-type CDL decreases feminine diapausing fee in non-circadian photoperiods. Total, our research exhibits that D. montana females measure night time size quantitatively, that the photoperiodic counter could play a distinguished however barely totally different position in further quick and further lengthy photoperiods and that northern strains present excessive stability towards perturbations within the photoperiod size and within the presence of LD cycles. These options are finest defined by the quantitative variations of the damped exterior coincidence mannequin.
Natural Zeitgebers Under Temperate Conditions Cannot Compensate for the Loss of a Functional Circadian Clock in Timing of a Vital Behavior in Drosophila

Interaction between intercourse willpower cascade and main signaling pathways throughout Drosophila eye improvement: Views for future analysis

Understanding molecular mechanisms of sexually dimorphic organ progress is a elementary downside of developmental biology. Current quantitative research confirmed that the Drosophila compound eye is a handy mannequin to review the willpower of the ultimate organ measurement. In Drosophila, females have bigger eyes than males and that is evident even after correction for the bigger physique measurement. Furthermore, feminine eyes embody extra ommatidia (photosensitive items) than male eyes and this distinction is specified on the third larval instar within the eye primordia referred to as eye imaginal discs. This will likely end in totally different visible capabilities between the 2 sexes and have behavioral penalties.
Regardless of rising proof on the genetic bases of eye measurement variation between totally different Drosophila species and strains, mechanisms accountable for within-species sexual dimorphism nonetheless stay elusive. Right here, we focus on a presumptive crosstalk between the intercourse willpower cascade and main signaling pathways throughout dimorphic eye improvement. Male- and female-specific isoforms of Doublesex (Dsx) protein are identified to regulate sex-specific differentiation within the somatic tissues. Nonetheless, no information on Dsx perform throughout eye disc progress and patterning are presently accessible.
Remarkably, Intercourse deadly (Sxl), the intercourse willpower change protein, was proven to straight have an effect on Hedgehog (Hh) and Notch (N) signaling within the Drosophila wing disc. The similarity of signaling pathways concerned within the wing and eye disc progress means that Sxl is perhaps built-in into regulation of eye improvement. Dsx position within the eye disc requires additional investigation. We focus on presently accessible information on sex-biased gene expression within the Drosophila eye and spotlight views for future research.

DNA polymerase theta suppresses mitotic crossing over

Polymerase theta-mediated finish becoming a member of (TMEJ) is a chromosome break restore pathway that is ready to rescue the lethality related to the lack of proteins concerned in early steps in homologous recombination (e.g., BRCA1/2). That is because of the capacity of polymerase theta (Pol θ) to make use of resected, 3′ single stranded DNA tails to restore chromosome breaks. These resected DNA tails are additionally the beginning substrate for homologous recombination. Nonetheless, it stays unknown if TMEJ can compensate for the lack of proteins concerned in additional downstream steps throughout homologous recombination. Right here we present that the Holliday junction resolvases SLX4 and GEN1 are required for viability within the absence of Pol θ in Drosophila melanogaster, and lack of all three proteins ends in excessive ranges of apoptosis.
Flies poor in Pol θ and SLX4 are extraordinarily delicate to DNA damaging brokers, and mammalian cells require both Pol θ or SLX4 to outlive. Our outcomes recommend that TMEJ and Holliday junction formation/decision share a standard DNA substrate, seemingly a homologous recombination intermediate, that when left unrepaired results in cell demise. One main consequence of Holliday junction decision by SLX4 and GEN1 is cancer-causing lack of heterozygosity as a consequence of mitotic crossing over. We measured mitotic crossovers in flies after a Cas9-induced chromosome break, and noticed that this mutagenic type of restore is elevated within the absence of Pol θ.

Monoclonal COPB Antibody (monoclonal) (M08), Clone: 3E11
APR15551G 0.1mg
EUR 484
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Monoclonal FBL Antibody (monoclonal) (M09), Clone: 3E11
APR15927G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human FBL (monoclonal) (M09). The antibodies are raised in mouse and are from clone 3E11. This antibody is applicable in E

Monoclonal ATP7B Antibody (monoclonal) (M01), Clone: 3E11
APG02168G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human ATP7B (monoclonal) (M01). The antibodies are raised in mouse and are from clone 3E11. This antibody is applicable in WB, E

Monoclonal HIP1R Antibody (monoclonal) (M01), Clone: 3E11
APR12375G 0.05mg
EUR 484
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Monoclonal COPl Antibody (monoclonal) (M01), Clone: 3E11
AMM03405G 0.1mg
EUR 484
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Monoclonal HERPUD1 Antibody (monoclonal) (M01), Clone: 3E11
AMM03617G 0.1mg
EUR 484
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Monoclonal ID3 Antibody (monoclonal) (M02), Clone: 3E11
AMM03649G 0.1mg
EUR 484
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Monoclonal LY6H Antibody (monoclonal) (M01), Clone: 3E11
AMM03754G 0.1mg
EUR 484
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Monoclonal MAP2K5 Antibody (monoclonal) (M11), Clone: 3E11
AMM03762G 0.1mg
EUR 484
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Monoclonal SMARCB1 Antibody (monoclonal) (M01), Clone: 3E11
AMM04112G 0.1mg
EUR 484
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Monoclonal PDLIM5 Antibody (monoclonal) (M01), Clone: 3E11-F6
APR12791G 0.1mg
EUR 484
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Anti Mummichog Vitellogenin Monoclonal Antibody (Clone No. 3E11)
KH005
EUR 544
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anti-HDAC3 (3E11)
LF-MA10133 100 ug
EUR 363
Description: Mouse monoclonal to HDAC3

Anti-Twist (3E11)
YF-MA10977 100 ug
EUR 363
Description: Mouse monoclonal to Twist

Anti-cvHSP (3E11)
YF-MA11450 100 ug
EUR 363
Description: Mouse monoclonal to cvHSP

Anti-AKT1 (3E11)
YF-MA11876 100 ug
EUR 363
Description: Mouse monoclonal to AKT1

Anti-OSGIN2 (3E11)
YF-MA12209 100 ug
EUR 363
Description: Mouse monoclonal to OSGIN2

Anti-FMRP (3E11)
YF-MA13101 100 ug
EUR 363
Description: Mouse monoclonal to FMRP

Anti-MCM3 (3E11)
YF-MA14152 100 ug
EUR 363
Description: Mouse monoclonal to MCM3

Anti-NHLH2 (3E11)
YF-MA14458 100 ug
EUR 363
Description: Mouse monoclonal to NHLH2

Anti-POMC (3E11)
YF-MA14807 100 ug
EUR 363
Description: Mouse monoclonal to POMC

Anti-RPL23A (3E11)
YF-MA15244 100 ug
EUR 363
Description: Mouse monoclonal to RPL23A

Anti-Psoriasin (3E11)
YF-MA15314 50 ug
EUR 363
Description: Mouse monoclonal to Psoriasin

Anti-Psoriasin (3E11)
YF-MA15315 200 ul
EUR 363
Description: Mouse monoclonal to Psoriasin

Anti-Osteopontin (3E11)
YF-MA15581 100 ug
EUR 363
Description: Mouse monoclonal to Osteopontin

Anti-TCF2 (3E11)
YF-MA15765 100 ug
EUR 363
Description: Mouse monoclonal to TCF2

Anti-KLF10 (3E11)
YF-MA15849 100 ug
EUR 363
Description: Mouse monoclonal to KLF10

Anti-ZNF187 (3E11)
YF-MA16192 100 ug
EUR 363
Description: Mouse monoclonal to ZNF187

Anti-CER1 (3E11)
YF-MA16795 100 ug
EUR 363
Description: Mouse monoclonal to CER1

Anti-TIP30 (3E11)
YF-MA17378 100 ug
EUR 363
Description: Mouse monoclonal to TIP30

Anti-CCRK (3E11)
YF-MA17926 100 ug
EUR 363
Description: Mouse monoclonal to CCRK

Anti-BTBD1 (3E11)
YF-MA18595 100 ug
EUR 363
Description: Mouse monoclonal to BTBD1

Anti-ALS2CR2 (3E11)
YF-MA18781 100 ug
EUR 363
Description: Mouse monoclonal to ALS2CR2

Anti-SPG (3E11)
YF-MA18829 50 ug
EUR 363
Description: Mouse monoclonal to SPG

Anti-MRPS36 (3E11)
YF-MA19657 100 ug
EUR 363
Description: Mouse monoclonal to MRPS36

Anti-MPO (3E11)
YF-MA20367 100 ug
EUR 363
Description: Mouse monoclonal to MPO

Anti-ARFGEF1 (3E11)
YF-MA20498 100 ug
EUR 363
Description: Mouse monoclonal to ARFGEF1

Monoclonal Ku (p70/p80)Mouse Monoclonal Antibody [Clone KU729], Clone: KU729
AMM00210G 0.5ml
EUR 484
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Monoclonal mouse Splunc2 Antibody, Clone: 1F12
APR07136G 0.1ml
EUR 528
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Monoclonal mouse Lplunc1 Antibody, Clone: 4H2
APR08492G 0.1ml
EUR 528
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Monoclonal mouse Lplunc1 Antibody, Clone: 1F11E3
APR08493G 0.1ml
EUR 528
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Monoclonal Mouse Bmi1 Antibody, Clone: 353CT22.4.4
AMM02383G 0.1ml
EUR 484
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Monoclonal NGFR Antibody (Clone # 8G3G10), Clone: Clone # 8G3G10
AMM06686G 0.1ml
EUR 484
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Monoclonal S100A8 Antibody (Clone IMG48M7C7), Clone: Clone IMG48M7C7
AMM00015G 0.1mg
EUR 528
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Monoclonal PDGFR Antibody (Clone # 275CT1), Clone: Clone # 275CT1
AMM00020G 0.05ml
EUR 484
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Monoclonal CD11c FITC Monoclonal Antibody (Clone 3.9), Clone: 3.9
APR15331G 50 tests
EUR 484
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Monoclonal CD28 FITC Monoclonal Antibody (Clone CD28.2), Clone: CD28.2
AMM00025G 0.05mg
EUR 396
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anti-Progesteron Receptor (3E11)
LF-MA10230 100 ug
EUR 363
Description: Mouse monoclonal to Progesteron Receptor

Anti-ORC2 (3E11-1G5)
YF-MA10652 100 ug
EUR 363
Description: Mouse monoclonal to ORC2

Anti-PDLIM5 (3E11-F6)
YF-MA11302 100 ug
EUR 363
Description: Mouse monoclonal to PDLIM5

Anti-IkB beta (3E11)
YF-MA14442 100 ug
EUR 363
Description: Mouse monoclonal to IkB beta

Monoclonal CST3 Antibody (monoclonal), Clone: 1H4
AMM03425G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human CST3 (monoclonal). The antibodies are raised in Mouse and are from clone 1H4. This antibody is applicable in WB

Monoclonal TNFSF18 Antibody (monoclonal), Clone: 2E11
AMM04221G 0.1mg
EUR 484
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Monoclonal FTL Antibody (monoclonal), Clone: 4G7
AMM04622G 0.1mg
EUR 484
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Monoclonal HEXA Antibody (clone AT20F1), Clone: AT20F1
APC00059G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human HEXA (clone AT20F1). The antibodies are raised in Mouse and are from clone AT20F1. This antibody is applicable in WB and IHC-P, E

Monoclonal MAG Antibody (clone 3C7), Clone: 3C7
APC00061G 0.05mg
EUR 528
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Monoclonal MAP1B Antibody (clone 3G5), Clone: 3G5
APC00063G 0.1ml
EUR 484
Description: A Monoclonal antibody against Human MAP1B (clone 3G5). The antibodies are raised in Mouse and are from clone 3G5. This antibody is applicable in IHC-P, IF

Monoclonal DUX4 Antibody (clone P2B1), Clone: P2B1
APC00110G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human DUX4 (clone P2B1). The antibodies are raised in Mouse and are from clone P2B1. This antibody is applicable in WB and IHC-P, IF

Monoclonal CPS1 Antibody (clone 8H8), Clone: 8H8
APG02746G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human CPS1 (clone 8H8). The antibodies are raised in Mouse and are from clone 8H8. This antibody is applicable in WB and IHC-P, E

Monoclonal CTH Antibody (clone 2D6), Clone: 2D6
APG02819G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human CTH (clone 2D6). The antibodies are raised in Mouse and are from clone 2D6. This antibody is applicable in WB and IHC-P

Monoclonal CYP1A1 Antibody (clone 6G5), Clone: 6G5
APG02871G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human CYP1A1 (clone 6G5). The antibodies are raised in Mouse and are from clone 6G5. This antibody is applicable in WB and IHC-P, E

Monoclonal CAMK4 Antibody (clone 1A3), Clone: 1A3
APG03190G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human CAMK4 (clone 1A3). The antibodies are raised in Mouse and are from clone 1A3. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal CAMKK1 Antibody (clone 1F6), Clone: 1F6
APG03194G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human CAMKK1 (clone 1F6). The antibodies are raised in Mouse and are from clone 1F6. This antibody is applicable in WB and IHC-P, E

Monoclonal EMX2 Antibody (clone 4F7), Clone: 4F7
APG03285G 0.05mg
EUR 528
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Monoclonal RAPGEF6 Antibody (clone 2C5), Clone: 2C5
AMM07531G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human RAPGEF6 (clone 2C5). The antibodies are raised in Mouse and are from clone 2C5. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal SOCS1 Antibody (clone 4H1), Clone: 4H1
AMM07943G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human SOCS1 (clone 4H1). The antibodies are raised in Mouse and are from clone 4H1. This antibody is applicable in WB and IHC-P

Monoclonal STK16 Antibody (clone M2), Clone: M2
AMM08020G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human STK16 (clone M2). The antibodies are raised in Mouse and are from clone M2. This antibody is applicable in WB and IHC-P, E, RNAi

Monoclonal STK33 Antibody (clone 3F10), Clone: 3F10
AMM08027G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human STK33 (clone 3F10). The antibodies are raised in Mouse and are from clone 3F10. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal TNNI2 Antibody (clone 11E6), Clone: 11E6
AMM08268G 0.1mg
EUR 484
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Monoclonal TNNI2 Antibody (clone 2F12G2), Clone: 2F12G2
AMM08269G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human TNNI2 (clone 2F12G2). The antibodies are raised in Mouse and are from clone 2F12G2. This antibody is applicable in WB and IHC-P, IF, ICC, E, Flo

Monoclonal TTC1 Antibody (clone 4E3), Clone: 4E3
AMM08362G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human TTC1 (clone 4E3). The antibodies are raised in Mouse and are from clone 4E3. This antibody is applicable in WB and IHC-P, E

Monoclonal TUBB2B Antibody (clone AT5B3), Clone: AT5B3
AMM08382G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human TUBB2B (clone AT5B3). The antibodies are raised in Mouse and are from clone AT5B3. This antibody is applicable in IHC-P

Monoclonal VASP Antibody (clone 4D6), Clone: 4D6
AMM08458G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human VASP (clone 4D6). The antibodies are raised in Mouse and are from clone 4D6. This antibody is applicable in WB and IHC-P, IF, Flo

Monoclonal CD34 Antibody (clone EP88), Clone: EP88
AMR03190G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human CD34 (clone EP88). The antibodies are raised in Rabbit and are from clone EP88. This antibody is applicable in IHC-P, IHC-Fr

Monoclonal PLCG1 Antibody (clone 2B1), Clone: 2B1
AMR09352G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human PLCG1 (clone 2B1). The antibodies are raised in Mouse and are from clone 2B1. This antibody is applicable in WB and IHC-P, IP

Monoclonal PNMT Antibody (clone AT1C11), Clone: AT1C11
AMR09408G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human PNMT (clone AT1C11). The antibodies are raised in Mouse and are from clone AT1C11. This antibody is applicable in WB and IHC-P, E

Monoclonal PNPO Antibody (clone AT2C7), Clone: AT2C7
AMR09416G 0.05ml
EUR 484
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Monoclonal PON3 Antibody (clone 5G11), Clone: 5G11
AMR09422G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human PON3 (clone 5G11). The antibodies are raised in Mouse and are from clone 5G11. This antibody is applicable in WB and IHC-P

Monoclonal PTGES3 Antibody (clone JJ6), Clone: JJ6
AMR09608G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human PTGES3 (clone JJ6). The antibodies are raised in Mouse and are from clone JJ6. This antibody is applicable in WB and IHC-P, E, IP

Monoclonal PTP1B Antibody (Clone 107AT531), Clone: 107AT531
AMR09648G 0.1mg
EUR 528
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Monoclonal PYGM Antibody (clone 2C4), Clone: 2C4
AMR09675G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human PYGM (clone 2C4). The antibodies are raised in Mouse and are from clone 2C4. This antibody is applicable in WB and IHC-P, E

Monoclonal REG1A Antibody (clone 1A4), Clone: 1A4
AMR09710G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human REG1A (clone 1A4). The antibodies are raised in Mouse and are from clone 1A4. This antibody is applicable in IHC-P, IF, E

Monoclonal SDSL Antibody (clone M2), Clone: M2
AMR09854G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human SDSL (clone M2). The antibodies are raised in Mouse and are from clone M2. This antibody is applicable in WB and IHC-P, E

Monoclonal CD34 Antibody (clone MEC14.7), Clone: MEC14.7
AMRa00010G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human CD34 (clone MEC14.7). The antibodies are raised in Rat and are from clone MEC14.7. This antibody is applicable in IHC-P, IP, Flo

Monoclonal CD44 Antibody (clone IM7), Clone: IM7
AMRa00013G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human CD44 (clone IM7). The antibodies are raised in Rat and are from clone IM7. This antibody is applicable in WB and IHC-P, ICC, IP, IHC-Fr, Flo

Monoclonal EBI3 Antibody (clone DNT27), Clone: DNT27
AMRa00014G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human EBI3 (clone DNT27). The antibodies are raised in Rat and are from clone DNT27. This antibody is applicable in WB and IHC-P

Monoclonal SLC13A5 Antibody (clone 2G4), Clone: 2G4
APR09978G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human SLC13A5 (clone 2G4). The antibodies are raised in Mouse and are from clone 2G4. This antibody is applicable in WB and IHC-P, E

Monoclonal SLC22A1 Antibody (clone 2C5), Clone: 2C5
APR10013G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human SLC22A1 (clone 2C5). The antibodies are raised in Mouse and are from clone 2C5. This antibody is applicable in WB and IHC-P, E, Flo

Monoclonal SMAD3 Antibody (clone 2C12), Clone: 2C12
APR10161G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human SMAD3 (clone 2C12). The antibodies are raised in Mouse and are from clone 2C12. This antibody is applicable in WB and IHC-P, E

Monoclonal SMAD3 Antibody (clone AF9F7), Clone: AF9F7
APR10162G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human SMAD3 (clone AF9F7). The antibodies are raised in Mouse and are from clone AF9F7. This antibody is applicable in WB and IHC-P, E, IP

Monoclonal SOCS3 Antibody (clone SO1), Clone: SO1
APR10171G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human SOCS3 (clone SO1). The antibodies are raised in Mouse and are from clone SO1. This antibody is applicable in WB and IHC-P, E

Monoclonal SOD3 Antibody (clone 1H12), Clone: 1H12
APR10200G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human SOD3 (clone 1H12). The antibodies are raised in Mouse and are from clone 1H12. This antibody is applicable in WB and IHC-P, E, IP

Monoclonal STAT1 Antibody (clone AT1FA), Clone: AT1FA
APR10265G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human STAT1 (clone AT1FA). The antibodies are raised in Mouse and are from clone AT1FA. This antibody is applicable in WB and IHC-P, E

Monoclonal STAT1 Antibody (clone SM1), Clone: SM1
APR10266G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human STAT1 (clone SM1). The antibodies are raised in Mouse and are from clone SM1. This antibody is applicable in WB and IHC-P, IP

Monoclonal STAT5A Antibody (clone 9F7), Clone: 9F7
APR10279G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human STAT5A (clone 9F7). The antibodies are raised in Mouse and are from clone 9F7. This antibody is applicable in WB and IHC-P, IF, Flo

Monoclonal STAT5B Antibody (clone 2D1), Clone: 2D1
APR10281G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human STAT5B (clone 2D1). The antibodies are raised in Mouse and are from clone 2D1. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal STAT5B Antibody (clone 5D6), Clone: 5D6
APR10282G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human STAT5B (clone 5D6). The antibodies are raised in Mouse and are from clone 5D6. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal TDO2 Antibody (clone 4G2), Clone: 4G2
APR10390G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human TDO2 (clone 4G2). The antibodies are raised in Mouse and are from clone 4G2. This antibody is applicable in WB and IHC-P

Monoclonal TOM20 Antibody (clone 4F3), Clone: 4F3
APR10504G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human TOM20 (clone 4F3). The antibodies are raised in Mouse and are from clone 4F3. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal UQCRC1 Antibody (clone 1G6), Clone: 1G6
APR10666G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human UQCRC1 (clone 1G6). The antibodies are raised in Mouse and are from clone 1G6. This antibody is applicable in WB and IHC-P, Flo

Monoclonal VCP Antibody (clone 4A8), Clone: 4A8
APR10681G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human VCP (clone 4A8). The antibodies are raised in Mouse and are from clone 4A8. This antibody is applicable in WB and IHC-P, E

Monoclonal VCP Antibody (clone 4G9), Clone: 4G9
APR10682G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human VCP (clone 4G9). The antibodies are raised in Mouse and are from clone 4G9. This antibody is applicable in WB and IHC-P, IF, ICC, IP

Monoclonal VLDLR Antibody (clone 1H10), Clone: 1H10
APR10743G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human VLDLR (clone 1H10). The antibodies are raised in Mouse and are from clone 1H10. This antibody is applicable in WB and IHC-P, E

Monoclonal VNN1 Antibody (clone 4E11), Clone: 4E11
APR10746G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human VNN1 (clone 4E11). The antibodies are raised in Mouse and are from clone 4E11. This antibody is applicable in IHC-P, E

Monoclonal BPIFB1 Antibody (clone 2A5), Clone: 2A5
APR11011G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human BPIFB1 (clone 2A5). The antibodies are raised in Mouse and are from clone 2A5. This antibody is applicable in WB and IHC-P, IF, ICC, E, Flo

Monoclonal TWIST2 Antibody (clone 3C8), Clone: 3C8
APR17884G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human TWIST2 (clone 3C8). The antibodies are raised in Mouse and are from clone 3C8. This antibody is applicable in WB and IHC-P, E

Monoclonal DLX2 Antibody (clone 2B12), Clone: 2B12
APS00029G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human DLX2 (clone 2B12). The antibodies are raised in Mouse and are from clone 2B12. This antibody is applicable in WB and IHC-P, E

Monoclonal DLX2 Antibody (clone 2C8), Clone: 2C8
APS00030G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human DLX2 (clone 2C8). The antibodies are raised in Mouse and are from clone 2C8. This antibody is applicable in WB and IHC-P, E

Monoclonal ADRM1 Antibody (clone 3D11), Clone: 3D11
APR14857G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human ADRM1 (clone 3D11). The antibodies are raised in Mouse and are from clone 3D11. This antibody is applicable in WB and IHC-P, E

Monoclonal ARHGAP25 Antibody (clone 12G4), Clone: 12G4
APR15012G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human ARHGAP25 (clone 12G4). The antibodies are raised in Mouse and are from clone 12G4. This antibody is applicable in WB and IHC-P, IF, Flo

Monoclonal ARVCF Antibody (clone 5D2), Clone: 5D2
APR15077G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human ARVCF (clone 5D2). The antibodies are raised in Mouse and are from clone 5D2. This antibody is applicable in WB and IHC-P

Monoclonal BAIAP2L1 Antibody (clone 2A4), Clone: 2A4
APR15127G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human BAIAP2L1 (clone 2A4). The antibodies are raised in Mouse and are from clone 2A4. This antibody is applicable in WB and IHC-P, E

Monoclonal Calreticulin Antibody (Clone S75), Clone: S75
APR15257G 0.1mg
EUR 528
Description: A Monoclonal antibody against Human Calreticulin (Clone S75). The antibodies are raised in Mouse and are from clone S75. This antibody is applicable in WB and IHC

Monoclonal CD2 Antibody [Clone BH1], Clone: BH1
APR15338G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human CD2 [Clone BH1]. The antibodies are raised in Mouse and are from clone BH1. This antibody is applicable in FC

Monoclonal CD28 Antibody [Clone CB28], Clone: CB28
APR15342G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human CD28 [Clone CB28]. The antibodies are raised in Mouse and are from clone CB28. This antibody is applicable in FC

Monoclonal CD28 Antibody [Clone CB28], Clone: CB28
APR15343G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human CD28 [Clone CB28]. The antibodies are raised in Mouse and are from clone CB28. This antibody is applicable in FC

Monoclonal CD75 Antibody [Clone LN1], Clone: LN1
APR15358G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human CD75 [Clone LN1]. The antibodies are raised in Mouse and are from clone LN1. This antibody is applicable in WB and IHC, FC

Monoclonal CDKL1 Antibody (clone 1F12), Clone: 1F12
APR15374G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human CDKL1 (clone 1F12). The antibodies are raised in Mouse and are from clone 1F12. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal CDKL1 Antibody (clone 2H6), Clone: 2H6
APR15375G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human CDKL1 (clone 2H6). The antibodies are raised in Mouse and are from clone 2H6. This antibody is applicable in WB and IHC-P, E

Monoclonal CORO1B Antibody (clone 1E7), Clone: 1E7
APR15562G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human CORO1B (clone 1E7). The antibodies are raised in Mouse and are from clone 1E7. This antibody is applicable in WB and IHC-P, E

Monoclonal DIXDC1 Antibody (clone 6B6), Clone: 6B6
APR15744G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human DIXDC1 (clone 6B6). The antibodies are raised in Mouse and are from clone 6B6. This antibody is applicable in WB and IHC-P, IF

Monoclonal GBP1 Antibody (clone 4D10), Clone: 4D10
APR16091G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human GBP1 (clone 4D10). The antibodies are raised in Mouse and are from clone 4D10. This antibody is applicable in WB and IHC-P, E

Monoclonal GBP2 Antibody (clone 5C8), Clone: 5C8
APR16102G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human GBP2 (clone 5C8). The antibodies are raised in Mouse and are from clone 5C8. This antibody is applicable in WB and IHC-P, IF, Flo

Monoclonal GGA1 Antibody (clone 3F11), Clone: 3F11
APR16128G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human GGA1 (clone 3F11). The antibodies are raised in Mouse and are from clone 3F11. This antibody is applicable in WB and IHC-P, E

Monoclonal GIMAP4 Antibody (clone 1C6), Clone: 1C6
APR16138G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human GIMAP4 (clone 1C6). The antibodies are raised in Mouse and are from clone 1C6. This antibody is applicable in WB and IHC-P, IF, Flo

Monoclonal HCLS1 Antibody (clone 2A8), Clone: 2A8
APR16675G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human HCLS1 (clone 2A8). The antibodies are raised in Mouse and are from clone 2A8. This antibody is applicable in WB and IHC-P, E

Monoclonal HIPK1 Antibody (clone 1D6), Clone: 1D6
APR16694G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human HIPK1 (clone 1D6). The antibodies are raised in Mouse and are from clone 1D6. This antibody is applicable in IHC-P, E

Monoclonal MFAP4 Antibody (clone AT12D11), Clone: AT12D11
APR17358G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human MFAP4 (clone AT12D11). The antibodies are raised in Mouse and are from clone AT12D11. This antibody is applicable in WB and IHC-P, E

Monoclonal MLKL Antibody (clone 3B2), Clone: 3B2
APR17395G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human MLKL (clone 3B2). The antibodies are raised in Mouse and are from clone 3B2. This antibody is applicable in WB and IHC-P, E

Monoclonal Moesin Antibody [Clone MSN491], Clone: MSN491
APR17407G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human Moesin [Clone MSN491]. The antibodies are raised in Mouse and are from clone MSN491. This antibody is applicable in WB and IHC, FC, IP, E

Monoclonal MYH9 Antibody (clone 2B3), Clone: 2B3
APR17494G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human MYH9 (clone 2B3). The antibodies are raised in Mouse and are from clone 2B3. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal MYH9 Antibody (clone 4H3), Clone: 4H3
APR17495G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human MYH9 (clone 4H3). The antibodies are raised in Mouse and are from clone 4H3. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal OCRL Antibody (clone 4A6), Clone: 4A6
APR17655G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human OCRL (clone 4A6). The antibodies are raised in Mouse and are from clone 4A6. This antibody is applicable in WB and IHC-P, E

Monoclonal PHF7 Antibody (clone 1A11), Clone: 1A11
APR17842G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human PHF7 (clone 1A11). The antibodies are raised in Mouse and are from clone 1A11. This antibody is applicable in WB and IHC-P, IF, Flo

Monoclonal ABHD5 Antibody (clone 1F3), Clone: 1F3
APG01441G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human ABHD5 (clone 1F3). The antibodies are raised in Mouse and are from clone 1F3. This antibody is applicable in WB and IHC-P, E

Monoclonal ACAT1 Antibody (clone AT2C5), Clone: AT2C5
APG01466G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human ACAT1 (clone AT2C5). The antibodies are raised in Mouse and are from clone AT2C5. This antibody is applicable in WB and IHC-P, E

Monoclonal ACOT9 Antibody (clone 4E4), Clone: 4E4
APG01503G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human ACOT9 (clone 4E4). The antibodies are raised in Mouse and are from clone 4E4. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal ACTN4 Antibody (clone 4D10), Clone: 4D10
APG01523G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human ACTN4 (clone 4D10). The antibodies are raised in Mouse and are from clone 4D10. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal AKR1B10 Antibody (clone 1A6), Clone: 1A6
APG01656G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human AKR1B10 (clone 1A6). The antibodies are raised in Mouse and are from clone 1A6. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal AKT2 Antibody (clone 1B6), Clone: 1B6
APG01703G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human AKT2 (clone 1B6). The antibodies are raised in Mouse and are from clone 1B6. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal ALDH1L1 Antibody (clone 2A6), Clone: 2A6
APG01736G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human ALDH1L1 (clone 2A6). The antibodies are raised in Mouse and are from clone 2A6. This antibody is applicable in WB and IHC-P, Flo

Monoclonal ALDH1L1 Antibody (clone 3E9), Clone: 3E9
APG01737G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human ALDH1L1 (clone 3E9). The antibodies are raised in Mouse and are from clone 3E9. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal ALDH1L1 Antibody (clone 7G8), Clone: 7G8
APG01738G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human ALDH1L1 (clone 7G8). The antibodies are raised in Mouse and are from clone 7G8. This antibody is applicable in WB and IHC-P, IF, Flo

Monoclonal ALDH2 Antibody (Clone # 138CT22.3.8), Clone: 138CT22.3.8
APG01749G 0.1ml
EUR 484
Description: A Monoclonal antibody against Human ALDH2 (Clone # 138CT22.3.8). The antibodies are raised in Mouse and are from clone 138CT22.3.8. This antibody is applicable in WB, IHC and IF, FC

Monoclonal AMACR Antibody (clone 2A10F3), Clone: 2A10F3
APG01846G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human AMACR (clone 2A10F3). The antibodies are raised in Mouse and are from clone 2A10F3. This antibody is applicable in WB and IHC-P, IF, E

Monoclonal AMY2B Antibody (clone 4B5), Clone: 4B5
APG01865G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human AMY2B (clone 4B5). The antibodies are raised in Mouse and are from clone 4B5. This antibody is applicable in WB and IHC-P

Monoclonal ATP5E Antibody (clone 2F3), Clone: 2F3
APG02119G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human ATP5E (clone 2F3). The antibodies are raised in Mouse and are from clone 2F3. This antibody is applicable in WB and IHC-P, E

Monoclonal ATP6V1B2 Antibody (clone 2A5), Clone: 2A5
APG02143G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human ATP6V1B2 (clone 2A5). The antibodies are raised in Mouse and are from clone 2A5. This antibody is applicable in WB and IHC-P, E

Monoclonal BAX Antibody (clone 6A7), Clone: 6A7
APG02213G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human BAX (clone 6A7). The antibodies are raised in Mouse and are from clone 6A7. This antibody is applicable in WB and IHC-P, IP

Monoclonal CBR3 Antibody (clone AT3C5), Clone: AT3C5
APG02457G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human CBR3 (clone AT3C5). The antibodies are raised in Mouse and are from clone AT3C5. This antibody is applicable in WB and IHC-P, E

Monoclonal CCS Antibody (clone 1G1), Clone: 1G1
APG02474G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human CCS (clone 1G1). The antibodies are raised in Mouse and are from clone 1G1. This antibody is applicable in WB and IHC-P, E

Monoclonal CCS Antibody (clone 3A1), Clone: 3A1
APG02475G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human CCS (clone 3A1). The antibodies are raised in Mouse and are from clone 3A1. This antibody is applicable in WB and IHC-P, E, IP

Monoclonal CD147 Antibody [Clone CB43], Clone: CB43
APG02480G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human CD147 [Clone CB43]. The antibodies are raised in Mouse and are from clone CB43. This antibody is applicable in IHC, IF

Monoclonal CD38 Antibody (clone 6E12D), Clone: 6E12D
APG02493G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human CD38 (clone 6E12D). The antibodies are raised in Mouse and are from clone 6E12D. This antibody is applicable in WB and IHC-P, E

Monoclonal CD38 Antibody (clone HIT2), Clone: HIT2
APG02494G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human CD38 (clone HIT2). The antibodies are raised in Mouse and are from clone HIT2. This antibody is applicable in WB and IHC-P, IHC-Fr, Flo

Monoclonal CD38 Antibody (clone HIT2), Clone: HIT2
APG02495G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human CD38 (clone HIT2). The antibodies are raised in Mouse and are from clone HIT2. This antibody is applicable in IHC-P, IHC-Fr, Flo

Monoclonal CISD1 Antibody (clone AT1A8), Clone: AT1A8
APG02604G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human CISD1 (clone AT1A8). The antibodies are raised in Mouse and are from clone AT1A8. This antibody is applicable in WB and IHC-P, E

Monoclonal CLIC5 Antibody (clone 1E6), Clone: 1E6
APG02659G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human CLIC5 (clone 1E6). The antibodies are raised in Mouse and are from clone 1E6. This antibody is applicable in WB and IHC-P, E

Monoclonal COMMD1 Antibody (clone 2E2), Clone: 2E2
APG02691G 0.05ml
EUR 484
Description: A Monoclonal antibody against Human COMMD1 (clone 2E2). The antibodies are raised in Mouse and are from clone 2E2. This antibody is applicable in WB and IHC-P, Flo

Monoclonal COX17 Antibody (clone 4G2), Clone: 4G2
APG02709G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human COX17 (clone 4G2). The antibodies are raised in Mouse and are from clone 4G2. This antibody is applicable in WB and IHC-P, E

Monoclonal NDRG4 Antibody (clone 2G3), Clone: 2G3
AMM06585G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human NDRG4 (clone 2G3). The antibodies are raised in Mouse and are from clone 2G3. This antibody is applicable in WB and IHC-P, E

Monoclonal Neuroserpin Antibody (clone 1D10), Clone: 1D10
AMM06649G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human Neuroserpin (clone 1D10). The antibodies are raised in Mouse and are from clone 1D10. This antibody is applicable in WB and IHC-P, E

Monoclonal NR1D1 Antibody (clone 4F6), Clone: 4F6
AMM06804G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human NR1D1 (clone 4F6). The antibodies are raised in Mouse and are from clone 4F6. This antibody is applicable in WB and IHC-P, IF, E, RNAi

Monoclonal OLIG2 Antibody (clone 3C9), Clone: 3C9
AMM06897G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human OLIG2 (clone 3C9). The antibodies are raised in Mouse and are from clone 3C9. This antibody is applicable in WB and IHC-P, E

Monoclonal EDEM2 Antibody (clone 2E4), Clone: 2E4
AMM07004G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human EDEM2 (clone 2E4). The antibodies are raised in Mouse and are from clone 2E4. This antibody is applicable in WB and IHC-P, E

Monoclonal PDE9A Antibody (clone 1E1), Clone: 1E1
AMM07065G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human PDE9A (clone 1E1). The antibodies are raised in Mouse and are from clone 1E1. This antibody is applicable in WB and IHC-P, E
This demonstrates that TMEJ can perform upstream of the Vacation junction resolvases to guard cells from lack of heterozygosity. Our work argues that Pol θ can thus compensate for the lack of the Holliday junction resolvases by utilizing homologous recombination intermediates, suppressing mitotic crossing over and preserving the genomic stability of cells.
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