Downregulation of TOP2 modulates neurodegeneration caused by GGGGCC expanded repeats
GGGGCC repeats in a non-coding area of the C9orf72 gene have been recognized as a significant genetic reason for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. We beforehand confirmed that the GGGGCC expanded repeats alone had been ample to trigger neurodegeneration in Drosophila. Current proof signifies that GGGGCC expanded repeats can modify numerous gene transcriptomes. To find out the function of those genes in GGGGCC-mediated neurotoxicity, we screened a longtime Drosophila mannequin expressing GGGGCC expanded repeats on this examine.
Our outcomes confirmed that knockdown of the DNA topoisomerase II (Top2) gene can particularly modulate GGGGCC-associated neurodegeneration of the attention. Moreover, chemical inhibition of Top2 or siRNA-induced Top2 downregulation might alleviate the GGGGCC-mediated neurotoxicity in Drosophila assessed by eye neurodegeneration and locomotion impairment. In contrast, upregulated Top2 ranges had been detected in Drosophila strains, and furthermore, TOP2A degree was additionally upregulated in Neuro-2a cells expressing GGGGCC expanded repeats, in addition to within the brains of Sod1G93A mannequin mice.
This indicated that elevated ranges of TOP2A could also be concerned in a pathway widespread to the pathophysiology of distinct ALS varieties. Furthermore, by means of RNA-sequencing, a complete of 67 genes, concerned within the pathways of intracellular signaling cascades, peripheral nervous system improvement, et al, had been recognized as potential targets of TOP2A to modulate GGGGCC-mediated neurodegeneration.
Single-cell transcriptomics of the Drosophila wing disc reveals instructive epithelium-to-myoblast interactions
In each vertebrates and invertebrates, producing a purposeful appendage requires interactions between ectoderm-derived epithelia and mesoderm-derived cells. To analyze such interactions, we used single-cell transcriptomics to generate a temporal cell atlas of the Drosophila wing disc from two developmental time factors. Utilizing these information, we visualized gene expression utilizing a multi-layered mannequin of the wing disc and catalogued ligand-receptor pairs that would mediate signaling between epithelial cells and grownup muscle precursors (AMPs).
We discovered that localized expression of the FGF ligands, Thisbe and Pyramus, within the disc epithelium regulates the quantity and placement of the AMPs. As well as, Hedgehog ligand from the epithelium prompts a particular transcriptional program inside adjoining AMP cells, outlined by AMP-specific targets Neurotactin and midline, that’s important for correct formation of direct flight muscle groups. Extra usually, our annotated temporal cell atlas supplies an organ-wide view of potential cell-cell interactions between epithelial and myogenic cells.

Identification and purposeful characterization of odorant-binding proteins 69a and 76a of Drosophila suzukii
The fruit fly Drosophila suzukii is a fruit crop pest that causes a extreme financial risk to smooth summer time fruit worldwide. The male intercourse pheromone, cis-vaccenyl acetate (cVA) has a number of capabilities in intra-species communication in Drosophila melanogaster, which is required in male to suppress male-male courtship. D. suzukii males don’t produce cVA; nonetheless, the odorant receptor for cVA (Or67d) remains to be purposeful. The dearth of cVA in D. suzukii casts the query of whether or not this pheromone may need been changed by one other compound much like cVA that disrupts mating in D. suzukii.
As a way to deal with this query, we cloned two D. suzukii grownup antenna-specific odorant-binding proteins (OBPs) DsOBP69a and DsOBP76a and aligned with their D. melanogaster orthologues. Furthermore, we examined the binding properties of the newly recognized recombinant proteins in opposition to 26 potential ligands together with cVA, utilizing the fluorescence-based ligand binding assay. The alignment confirmed that DsOBP69a and DsOBP76a, have six conserved cysteines and belong to the basic OBP household. Moreover, our outcomes revealed that cVA didn’t bind to DsOBP69a or DsOBP76a proteins.
Curiously, the floral odorant β-ionone and the bitter substance berberine chloride and coumarin displayed excessive binding potential. Additionally it is value noting that DsOBP69a and DsOBP76a have completely different affinities to (Z)-7-Tricosene which will replicate completely different purposeful roles. These findings counsel that DsOBP69a and DsOBP76a are doubtlessly concerned in olfaction and gustation of D. suzukii.
Differential Necessities for Mediator Complicated Subunits in Drosophila melanogaster Host Protection Towards Fungal and Bacterial Pathogens
The humoral immune response to bacterial or fungal infections in Drosophila depends largely on a transcriptional response mediated by the Toll and Immune deficiency NF-κB pathways. Antimicrobial peptides are potent effectors of those pathways and permit the organism to assault invading pathogens. Dorsal-related Immune Issue (DIF), a transcription issue regulated by the Toll pathway, is required within the host protection in opposition to fungal and a few Gram-positive bacterial infections. The Mediator advanced is concerned within the initiation of transcription of most RNA polymerase B (PolB)-dependent genes by forming a purposeful bridge between transcription components certain to enhancer areas and the gene promoter area after which recruiting the PolB pre-initiation advanced. Mediator is fashioned by a number of modules that every contains a number of subunits.
The Med17 subunit of the top module of Mediator has been proven to be required for the expression of Drosomycin, which encodes a potent antifungal peptide, by binding to DIF. Thus, Mediator is predicted to mediate the host protection in opposition to pathogens managed by the Toll pathway-dependent innate immune response. Right here, we first deal with the Med31 subunit of the center module of Mediator and discover that it’s required in host protection in opposition to Aspergillus fumigatus, Enterococcus faecalis, and injected however not topically-applied Metarhizium robertsii.
Thus, host protection in opposition to M. robertsii requires Dif however not essentially Med31 within the two distinct an infection fashions. The induction of some Toll-pathway-dependent genes is decreased after a problem of Med31 RNAi-silenced flies with both A. fumigatus or E. faecalis, whereas these flies exhibit regular phagocytosis and melanization. We’ve additional examined most Mediator subunits utilizing RNAi by monitoring their survival after challenges to a number of different microbial infections recognized to be fought off by means of DIF.
Th1l ORF Vector (Mouse) (pORF) |
ORF059509 |
ABM |
1.0 ug DNA |
EUR 506 |
Anti-TH1L (3C9) |
YF-MA18524 |
Abfrontier |
200 ul |
EUR 363 |
Description: Mouse monoclonal to TH1L |
TH1L Blocking Peptide |
33R-3227 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TH1L antibody, catalog no. 70R-9546 |
TH1L Blocking Peptide |
DF12771-BP |
Affbiotech |
1mg |
EUR 195 |
TH1L cloning plasmid |
CSB-CL815573HU-10ug |
Cusabio |
10ug |
EUR 607 |
|
Description: A cloning plasmid for the TH1L gene. |
TH1-Like (Drosophila) (TH1L) Antibody |
abx122033-100ug |
Abbexa |
100 ug |
EUR 391 |
|
TH1-Like (Drosophila) (TH1L) Antibody |
abx029378-400ul |
Abbexa |
400 ul |
EUR 523 |
|
TH1-Like (Drosophila) (TH1L) Antibody |
abx029378-80l |
Abbexa |
80 µl |
EUR 286 |
|
TH1-Like (Drosophila) (TH1L) Antibody |
abx432026-200ul |
Abbexa |
200 ul |
EUR 384 |
|
TH1-Like (Drosophila) (TH1L) Antibody |
abx238656-100ug |
Abbexa |
100 ug |
EUR 509 |
|
Th1l sgRNA CRISPR Lentivector set (Mouse) |
K3786501 |
ABM |
3 x 1.0 ug |
EUR 339 |
TH1L Recombinant Protein (Human) |
RP031426 |
ABM |
100 ug |
Ask for price |
TH1L Protein Vector (Mouse) (pPB-C-His) |
PV238034 |
ABM |
500 ng |
EUR 603 |
TH1L Protein Vector (Mouse) (pPB-N-His) |
PV238035 |
ABM |
500 ng |
EUR 603 |
TH1L Protein Vector (Mouse) (pPM-C-HA) |
PV238036 |
ABM |
500 ng |
EUR 603 |
TH1L Protein Vector (Mouse) (pPM-C-His) |
PV238037 |
ABM |
500 ng |
EUR 603 |
Th1l sgRNA CRISPR Lentivector (Mouse) (Target 1) |
K3786502 |
ABM |
1.0 ug DNA |
EUR 154 |
Th1l sgRNA CRISPR Lentivector (Mouse) (Target 2) |
K3786503 |
ABM |
1.0 ug DNA |
EUR 154 |
Th1l sgRNA CRISPR Lentivector (Mouse) (Target 3) |
K3786504 |
ABM |
1.0 ug DNA |
EUR 154 |
TH1L ORF Vector (Human) (pORF) |
ORF010476 |
ABM |
1.0 ug DNA |
EUR 95 |
Mouse Negative elongation factor D, Th1l ELISA KIT |
ELI-42483m |
Lifescience Market |
96 Tests |
EUR 865 |
TH1L sgRNA CRISPR Lentivector set (Human) |
K2367101 |
ABM |
3 x 1.0 ug |
EUR 339 |
Mouse Negative elongation factor C/D(TH1L) ELISA kit |
E03N0576-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Mouse Negative elongation factor C/D(TH1L) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Negative elongation factor C/D(TH1L) ELISA kit |
E03N0576-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Mouse Negative elongation factor C/D(TH1L) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Negative elongation factor C/D(TH1L) ELISA kit |
E03N0576-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Mouse Negative elongation factor C/D(TH1L) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Th1l sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse) |
K3786505 |
ABM |
3 x 1.0 ug |
EUR 376 |
ELISA kit for Mouse Negative elongation factor C/D (TH1L) |
KTE70377-48T |
Abbkine |
48T |
EUR 332 |
|
Description: Quantitative sandwich ELISA for measuring Mouse Negative elongation factor C/D (TH1L) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Mouse Negative elongation factor C/D (TH1L) |
KTE70377-5platesof96wells |
Abbkine |
5 plates of 96 wells |
EUR 2115 |
|
Description: Quantitative sandwich ELISA for measuring Mouse Negative elongation factor C/D (TH1L) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Mouse Negative elongation factor C/D (TH1L) |
KTE70377-96T |
Abbkine |
96T |
EUR 539 |
|
Description: Quantitative sandwich ELISA for measuring Mouse Negative elongation factor C/D (TH1L) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
TH1L 3'UTR Luciferase Stable Cell Line |
TU025510 |
ABM |
1.0 ml |
EUR 1394 |
Th1l 3'UTR Luciferase Stable Cell Line |
TU120436 |
ABM |
1.0 ml |
Ask for price |
Th1l 3'UTR GFP Stable Cell Line |
TU170436 |
ABM |
1.0 ml |
Ask for price |
TH1L 3'UTR GFP Stable Cell Line |
TU075510 |
ABM |
1.0 ml |
EUR 1394 |
TH1L Protein Vector (Human) (pPB-C-His) |
PV041901 |
ABM |
500 ng |
EUR 329 |
TH1L Protein Vector (Human) (pPB-N-His) |
PV041902 |
ABM |
500 ng |
EUR 329 |
TH1L Protein Vector (Human) (pPM-C-HA) |
PV041903 |
ABM |
500 ng |
EUR 329 |
TH1L Protein Vector (Human) (pPM-C-His) |
PV041904 |
ABM |
500 ng |
EUR 329 |
TH1L sgRNA CRISPR Lentivector (Human) (Target 1) |
K2367102 |
ABM |
1.0 ug DNA |
EUR 154 |
TH1L sgRNA CRISPR Lentivector (Human) (Target 2) |
K2367103 |
ABM |
1.0 ug DNA |
EUR 154 |
TH1L sgRNA CRISPR Lentivector (Human) (Target 3) |
K2367104 |
ABM |
1.0 ug DNA |
EUR 154 |
Human TH1-Like (Drosophila) (TH1L) ELISA Kit |
abx383733-96tests |
Abbexa |
96 tests |
EUR 911 |
|
Rabbit Anti-Human Haptoglobin Polyclonal Antibody(Affinity Purified) |
DPAB2047RH |
Creative Diagnostics |
1mg |
EUR 580 |
Mouse anti-Human CD4, Purified mAbConjugated Antibody |
C28010 |
SAB |
100ul |
EUR 397 |
Mouse anti-Human CD8, Purified mAbConjugated Antibody |
C28025 |
SAB |
100ul |
EUR 397 |
Mouse anti-Human CD14, Purified mAbConjugated Antibody |
C28050 |
SAB |
100ul |
EUR 397 |
Mouse anti-Human CD19, Purified mAbConjugated Antibody |
C28071 |
SAB |
100ul |
EUR 397 |
Mouse anti-Human CD45, Purified mAbConjugated Antibody |
C28141 |
SAB |
100ul |
EUR 397 |
Th1l sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1) |
K3786506 |
ABM |
1.0 ug DNA |
EUR 167 |
Th1l sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2) |
K3786507 |
ABM |
1.0 ug DNA |
EUR 167 |
Th1l sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3) |
K3786508 |
ABM |
1.0 ug DNA |
EUR 167 |
Mouse IgG1 Isotype Control Purified |
11-457-C025 |
ExBio |
0.025 mg |
EUR 88 |
Mouse IgG1 Isotype Control Purified |
11-457-C100 |
ExBio |
0.1 mg |
EUR 136 |
Mouse IgG2a Isotype Control Purified |
11-458-C025 |
ExBio |
0.025 mg |
EUR 88 |
Mouse IgG2a Isotype Control Purified |
11-458-C100 |
ExBio |
0.1 mg |
EUR 136 |
Mouse IgG3 Isotype Control Purified |
11-459-C025 |
ExBio |
0.025 mg |
EUR 88 |
Mouse IgG3 Isotype Control Purified |
11-459-C100 |
ExBio |
0.1 mg |
EUR 136 |
Mouse IgG1 Isotype Control Purified |
11-632-C025 |
ExBio |
0.025 mg |
EUR 87 |
Mouse IgG1 Isotype Control Purified |
11-632-C100 |
ExBio |
0.1 mg |
EUR 136 |
Mouse IgG2b Isotype Control Purified |
11-692-C025 |
ExBio |
0.025 mg |
EUR 88 |
Mouse IgG2b Isotype Control Purified |
11-692-C100 |
ExBio |
0.1 mg |
EUR 136 |
Mouse IgG2a Isotype Control Purified |
11-724-C025 |
ExBio |
0.025 mg |
EUR 88 |
Mouse IgG2a Isotype Control Purified |
11-724-C100 |
ExBio |
0.1 mg |
EUR 136 |
Mouse IgG2b Isotype Control Purified |
11-801-C025 |
ExBio |
0.025 mg |
EUR 88 |
Mouse IgG2b Isotype Control Purified |
11-801-C100 |
ExBio |
0.1 mg |
EUR 136 |
Mouse IgM Isotype Control Purified |
11-803-C025 |
ExBio |
0.025 mg |
EUR 87 |
Mouse IgM Isotype Control Purified |
11-803-C100 |
ExBio |
0.1 mg |
EUR 136 |
Antithrombin III, Mouse Plasma, purified |
ATH36-N-100 |
Alpha Diagnostics |
100 ug |
EUR 225 |
Mouse Recombinant purified Resistin protein |
RSTN15-R-25 |
Alpha Diagnostics |
25 ug |
EUR 773 |
Purified AAV-6 Antibody |
10R-2480AP |
Fitzgerald |
50 ug |
EUR 648 |
Description: Purified Anti-AAV-6 Monoclonal Antibody |
Porcine Negative elongation factor D, TH1L ELISA KIT |
ELI-42484p |
Lifescience Market |
96 Tests |
EUR 928 |
Ovalbumin, purified |
O705084 |
Bio Basic |
1g |
EUR 67.4 |
|
Human Negative elongation factor C/D(TH1L) ELISA kit |
E01N0576-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Human Negative elongation factor C/D(TH1L) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Negative elongation factor C/D(TH1L) ELISA kit |
E01N0576-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Human Negative elongation factor C/D(TH1L) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Negative elongation factor C/D(TH1L) ELISA kit |
E01N0576-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Human Negative elongation factor C/D(TH1L) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Negative elongation factor C/D(TH1L) ELISA kit |
E02N0576-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Rat Negative elongation factor C/D(TH1L) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Negative elongation factor C/D(TH1L) ELISA kit |
E02N0576-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Rat Negative elongation factor C/D(TH1L) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Negative elongation factor C/D(TH1L) ELISA kit |
E02N0576-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Rat Negative elongation factor C/D(TH1L) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Negative elongation factor C/D(TH1L) ELISA kit |
E06N0576-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Goat Negative elongation factor C/D(TH1L) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Negative elongation factor C/D(TH1L) ELISA kit |
E06N0576-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Goat Negative elongation factor C/D(TH1L) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Negative elongation factor C/D(TH1L) ELISA kit |
E06N0576-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Goat Negative elongation factor C/D(TH1L) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Negative elongation factor C/D(TH1L) ELISA kit |
E08N0576-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Canine Negative elongation factor C/D(TH1L) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Negative elongation factor C/D(TH1L) ELISA kit |
E08N0576-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Canine Negative elongation factor C/D(TH1L) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Negative elongation factor C/D(TH1L) ELISA kit |
E08N0576-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Canine Negative elongation factor C/D(TH1L) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Negative elongation factor C/D(TH1L) ELISA kit |
E07N0576-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Porcine Negative elongation factor C/D(TH1L) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Negative elongation factor C/D(TH1L) ELISA kit |
E07N0576-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Porcine Negative elongation factor C/D(TH1L) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Negative elongation factor C/D(TH1L) ELISA kit |
E07N0576-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Porcine Negative elongation factor C/D(TH1L) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Negative elongation factor C/D(TH1L) ELISA kit |
E04N0576-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit Negative elongation factor C/D(TH1L) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Negative elongation factor C/D(TH1L) ELISA kit |
E04N0576-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit Negative elongation factor C/D(TH1L) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Negative elongation factor C/D(TH1L) ELISA kit |
E04N0576-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit Negative elongation factor C/D(TH1L) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Negative elongation factor C/D(TH1L) ELISA kit |
E09N0576-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Monkey Negative elongation factor C/D(TH1L) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Negative elongation factor C/D(TH1L) ELISA kit |
E09N0576-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Monkey Negative elongation factor C/D(TH1L) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Negative elongation factor C/D(TH1L) ELISA kit |
E09N0576-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Monkey Negative elongation factor C/D(TH1L) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Negative elongation factor C/D, TH1L ELISA KIT |
ELI-39579h |
Lifescience Market |
96 Tests |
EUR 824 |
Mouse anti-Human CD3, Purified mAb |
28003-100ul |
SAB |
100ul |
EUR 252 |
Mouse anti-Human CD4, Purified mAb |
28010-100ul |
SAB |
100ul |
EUR 252 |
Mouse anti-Human CD8, Purified mAb |
28025-100ul |
SAB |
100ul |
EUR 252 |
Mouse anti-Human CD14, Purified mAb |
28050-100ul |
SAB |
100ul |
EUR 252 |
Mouse anti-Human CD19, Purified mAb |
28071-100ul |
SAB |
100ul |
EUR 252 |
Mouse anti-Human CD45, Purified mAb |
28141-100ul |
SAB |
100ul |
EUR 252 |
Mouse liver ferritin purified, ELISA grade |
FERT20-R-50 |
Alpha Diagnostics |
50 ug |
EUR 408 |
Mouse Recombinant (E.Coli) Purified Leptin Protein |
LEP11-R-1000 |
Alpha Diagnostics |
1 mg |
EUR 286 |
Mouse Recombinant (E.Coli) Purified Leptin Protein |
LEP11-R-5000 |
Alpha Diagnostics |
5 mg |
EUR 895 |
Recombinant Mouse Myeloperoxidase (MPO) Purified Protein |
MPO17-R-50 |
Alpha Diagnostics |
50 ug |
EUR 347 |
HIV1 p24 antibody (IgG purified) |
20-000702 |
Fitzgerald |
100 ug |
EUR 317 |
Description: Sheep polyclonal HIV1 p24 antibody (IgG purified) |
anti-LBR antibody, affinity-purified |
70-301 |
Sceti |
50ug |
EUR 362 |
Description: The anti-LBR antibody, affinity-purified is available in Europe and for worldwide shipping via Gentaur. |
AFP Antigen (Purified) |
E62C00201 |
EnoGene |
20ug |
EUR 382 |
CEA Antigen (Purified) |
E62C01001 |
EnoGene |
20ug |
EUR 382 |
Myoglobin antigen (Purified) |
E64C00401 |
EnoGene |
100ug |
EUR 375 |
Myoglobin antigen (Purified) |
E64C00401a |
EnoGene |
20ug |
EUR 343 |
Anti-Cytokeratins Purified |
11-108-C025 |
ExBio |
0.025 mg |
EUR 99 |
Anti-Cytokeratins Purified |
11-108-C100 |
ExBio |
0.1 mg |
EUR 158 |
Anti-MFG Purified |
11-113-C025 |
ExBio |
0.025 mg |
EUR 90 |
Anti-MFG Purified |
11-113-C100 |
ExBio |
0.1 mg |
EUR 140 |
Anti-p53 Purified |
11-114-C025 |
ExBio |
0.025 mg |
EUR 104 |
Anti-p53 Purified |
11-114-C100 |
ExBio |
0.1 mg |
EUR 167 |
Anti-CDK1 Purified |
11-115-C025 |
ExBio |
0.025 mg |
EUR 108 |
Anti-CDK1 Purified |
11-115-C100 |
ExBio |
0.1 mg |
EUR 177 |
Anti-hTSH Purified |
11-124-C025 |
ExBio |
0.025 mg |
EUR 90 |
Anti-hTSH Purified |
11-124-C100 |
ExBio |
0.1 mg |
EUR 140 |
Anti-hTSH Purified |
11-125-C025 |
ExBio |
0.025 mg |
EUR 90 |
Anti-hTSH Purified |
11-125-C100 |
ExBio |
0.1 mg |
EUR 140 |
Anti-hGH Purified |
11-126-C025 |
ExBio |
0.025 mg |
EUR 99 |
Anti-hGH Purified |
11-126-C100 |
ExBio |
0.1 mg |
EUR 158 |
Anti-Lactoferrin Purified |
11-128-C025 |
ExBio |
0.025 mg |
EUR 99 |
Anti-Lactoferrin Purified |
11-128-C100 |
ExBio |
0.1 mg |
EUR 158 |
Anti-Ikaros Purified |
11-159-C025 |
ExBio |
0.025 mg |
EUR 99 |
Anti-Ikaros Purified |
11-159-C100 |
ExBio |
0.1 mg |
EUR 158 |
Anti-PCNA Purified |
11-182-C025 |
ExBio |
0.025 mg |
EUR 99 |
Anti-PCNA Purified |
11-182-C100 |
ExBio |
0.1 mg |
EUR 158 |
Anti-NG2 Purified |
11-199-C025 |
ExBio |
0.025 mg |
EUR 99 |
Anti-NG2 Purified |
11-199-C100 |
ExBio |
0.1 mg |
EUR 158 |
Anti-Insulin Purified |
11-246-C025 |
ExBio |
0.025 mg |
EUR 99 |
Anti-Insulin Purified |
11-246-C100 |
ExBio |
0.1 mg |
EUR 158 |
Anti-MAP2 Purified |
11-253-C025 |
ExBio |
0.025 mg |
EUR 113 |
Anti-MAP2 Purified |
11-253-C100 |
ExBio |
0.1 mg |
EUR 186 |
Anti-Vimentin Purified |
11-254-C025 |
ExBio |
0.025 mg |
EUR 113 |
Anti-Vimentin Purified |
11-254-C100 |
ExBio |
0.1 mg |
EUR 186 |
Anti-GFAP Purified |
11-255-C025 |
ExBio |
0.025 mg |
EUR 113 |
Anti-GFAP Purified |
11-255-C100 |
ExBio |
0.1 mg |
EUR 186 |
Anti-Transferrin Purified |
11-258-C025 |
ExBio |
0.025 mg |
EUR 99 |
Anti-Transferrin Purified |
11-258-C100 |
ExBio |
0.1 mg |
EUR 158 |
Anti-HRP Purified |
11-262-C025 |
ExBio |
0.025 mg |
EUR 90 |
Anti-HRP Purified |
11-262-C100 |
ExBio |
0.1 mg |
EUR 140 |
We report that the host protection in opposition to particular pathogens includes a definite set of Mediator subunits with just one subunit for C. glabrata or Erwinia carotovora carotovora, a minimum of one for M. robertsii or a considerably prolonged repertoire for A. fumigatus (a minimum of eight subunits) and E. faecalis (eight subunits), with two subunits, Med6 and Med11 being required solely in opposition to A. fumigatus. Med31 however not Med17 is required in combating off injected M. robertsii conidia. Thus, the involvement of Mediator in Drosophila innate immunity is extra advanced than anticipated.
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