Category: Clia Kits

Downregulation of TOP2 modulates neurodegeneration caused by GGGGCC expanded repeats

GGGGCC repeats in a non-coding area of the C9orf72 gene have been recognized as a significant genetic reason for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. We beforehand confirmed that the GGGGCC expanded repeats alone had been ample to trigger neurodegeneration in Drosophila. Current proof signifies that GGGGCC expanded repeats can modify numerous gene transcriptomes. To

Read More
Transcriptomic analysis of feminizing somatic stem cells in the Drosophila testis reveal putative downstream effectors of the transcription factor Chinmo

The most effective examples of sexual dimorphism is the event and performance of the gonads, ovaries and testes, which produce sex-specific gametes, oocytes and spermatids, respectively. The event of those specialised germ cells requires sex-matched somatic assist cells. The sexual id of somatic gonadal cells is specified throughout growth and have to be actively maintained

Read More
Daily temperature cycles prolong lifespan and have sex-specific effects on peripheral clock gene expression in Drosophila melanogaster

Circadian rhythms optimize well being by coordinating the timing of physiological processes to match predictable every day environmental challenges. The circadian rhythm of physique temperature is regarded as an vital modulator of molecular clocks in peripheral tissues, however how every day temperature cycles influence physiological perform is unclear. Right here, we examined the impact of

Read More