Downregulation of TOP2 modulates neurodegeneration caused by GGGGCC expanded repeats

GGGGCC repeats in a non-coding area of the C9orf72 gene have been recognized as a significant genetic reason for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. We beforehand confirmed that the GGGGCC expanded repeats alone had been ample to trigger neurodegeneration in Drosophila. Current proof signifies that GGGGCC expanded repeats can modify numerous gene transcriptomes. To

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