Mad dephosphorylation at the nuclear pore is essential for asymmetric stem cell division
Stem cells divide asymmetrically to generate a stem cell and a differentiating daughter cell. But, it stays poorly understood how a stem cell and a differentiating daughter cell can obtain distinct ranges of area of interest sign and thus purchase completely different cell fates (self-renewal versus differentiation), regardless of being adjoining to one another and thus seemingly uncovered to comparable ranges of area of interest signaling. Within the Drosophila ovary, germline stem cells (GSCs) are maintained by brief vary bone morphogenetic protein (BMP) signaling; the BMP ligands activate a receptor that phosphorylates the downstream molecule moms in opposition to decapentaplegic (Mad).
Phosphorylated Mad (pMad) accumulates within the GSC nucleus and prompts the stem cell transcription program. Right here, we exhibit that pMad is extremely concentrated within the nucleus of the GSC, whereas it rapidly decreases within the nucleus of the differentiating daughter cell, the precystoblast (preCB), earlier than the completion of cytokinesis. We present {that a} identified Mad phosphatase, Dullard (Dd), is required for the uneven partitioning of pMad. Our mathematical modeling recapitulates the excessive sensitivity of the ratio of pMad ranges to the Mad phosphatase exercise and explains how the asymmetry arises in a shared cytoplasm. Collectively, these research reveal a mechanism for breaking the symmetry of daughter cells throughout uneven stem cell division.
Suppression of mixture and amyloid formation by a novel intrinsically disordered area in metazoan Hsp110 chaperones
Molecular chaperones preserve proteostasis by making certain the correct folding of polypeptides. Lack of proteostasis has been linked to quite a few neurodegenerative problems together with Alzheimer’s, Parkinson’s, and Huntington’s illness. Hsp110 is expounded to the canonical Hsp70 class of protein folding molecular chaperones and interacts with Hsp70 as a nucleotide trade issue (NEF). Along with its NEF exercise, Hsp110 possesses an Hsp70-like substrate binding area (SBD) whose organic roles stay undefined. Earlier work in Drosophila melanogaster has implicated the only real Hsp110 gene (Hsc70cb) in proteinopathic neurodegeneration.
We hypothesize that along with its function as an Hsp70 NEF, Drosophila Hsp110 might perform as a protecting protein “holdase”, stopping the aggregation of unfolded polypeptides through the SBD-b subdomain. We exhibit for the primary time that Drosophila Hsp110 successfully prevents aggregation of the mannequin substrate citrate synthase. We additionally report the invention of a redundant and heretofore unknown potent holdase capability in a 138 amino-acid area of Hsp110 carboxyl-terminal to each SBD-b and SBD-α (henceforth known as the C-terminal extension).
This sequence is extremely conserved in metazoan Hsp110 genes, fully absent from fungal representatives, and is computationally predicted to include an intrinsically disordered area (IDR). We exhibit that this IDR sequence inside the human Hsp110s, Apg-1 and Hsp105α, inhibits the formation of amyloid Aβ-42 and α-synuclein fibrils in vitro however can not mediate fibril disassembly. Collectively these findings set up capability for metazoan Hsp110 chaperones to suppress each common protein aggregation and amyloidogenesis, elevating the potential for exploitation of this IDR for therapeutic profit.
Digital screening identifies a novel piperazine-based insect juvenile hormone agonist
Juvenile hormone (JH) agonists represent a subclass of insect development regulators and play necessary roles in insect pest administration. On this work, a multi-step digital screening program was executed to search out novel JH agonists. A database of 5 million purchasable compounds was sequentially processed with three computational filters: (i) form and chemical similarity as in comparison with identified JH-active compounds; (ii) molecular docking simulations in opposition to a Drosophila JH receptor, methoprene-tolerant; and (iii) free vitality calculation of ligand-receptor binding utilizing a modified MM/PBSA (molecular mechanics/Poisson-Boltzmann floor space) protocol.
The 11 candidates that handed the three filters have been evaluated in a luciferase reporter assay, resulting in the identification of a success compound that accommodates a piperazine ring system (EC50=870 nM). This compound is structurally dissimilar to identified JH agonists and synthetically straightforward to entry; due to this fact, it’s a promising place to begin for additional construction optimization.
Transporter-mediated ecdysteroid trafficking throughout cell membranes: A novel goal for insect development regulators
Ecdysteroids are a category of steroid hormones in arthropods that management molting and metamorphosis via interplay with intracellular nuclear receptors. In distinction to the in depth literature describing their biosynthetic pathways and signaling parts, little has been identified about how these hormones are touring into and out of the cells via lipid bilayers of the cell membranes. Just lately, a collection of research performed within the fruit fly Drosophila melanogaster revealed that membrane transporters have vital features in trafficking ecdysteroids throughout cell membranes, difficult the classical easy diffusion mannequin of steroid hormone transport. Right here we summarize latest advances in our understanding of membrane transporters concerned in ecdysteroid signaling in Drosophila, with explicit give attention to Ecdysone Importer (EcI) that’s concerned in ecdysteroid uptake in peripheral tissues. We then talk about the potential benefit of EcI blockers as a novel pest administration instrument as in comparison with classical insect development regulators.
Glial Hedgehog signalling and lipid metabolism regulate neural stem cell proliferation in Drosophila
The ultimate dimension and performance of the grownup central nervous system (CNS) are decided by neuronal lineages generated by neural stem cells (NSCs) within the creating mind. In Drosophila, NSCs known as neuroblasts (NBs) reside inside a specialised microenvironment known as the glial area of interest. Right here, we discover non-autonomous glial regulation of NB proliferation. We present that lipid droplets (LDs) which reside inside the glial area of interest are carefully related to the signalling molecule Hedgehog (Hh).
) ELISA kit for Mouse Slit homolog 1 protein (SLIT1) |
|
KTE70417-96T |
Abbkine |
96T |
EUR 646.8 |
|
|
|
Description: Quantitative sandwich ELISA for measuring Mouse Slit homolog 1 protein (SLIT1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
 Mouse Slit Homolog 2 Protein ELISA Kit |
|
IMSSLIT2KT |
Innovative research |
each |
EUR 702 |
|
|
|
Description: Mouse Slit Homolog 2 Protein ELISA Kit |
 Mouse Slit homolog 2 protein, Slit2 ELISA KIT |
|
ELI-02346m |
Lifescience Market |
96 Tests |
EUR 1038 |
 Mouse Slit2/ Slit homolog 2 protein ELISA Kit |
|
E1378Mo |
Sunlong |
1 Kit |
EUR 685.2 |
 ELISA Kit) Mouse Slit2( Slit homolog 2 protein) ELISA Kit |
|
EM0434 |
FN Test |
96T |
EUR 681.12 |
|
|
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.094 ng/ml |
 ELISA Kit) Mouse Slit homolog 2 protein (SLIT2) ELISA Kit |
|
AE18234MO-48Tests |
Abebio |
48 Tests |
EUR 325 |
|
|
|
Description: Mouse (Mus musculus) |
Mouse Slit homolog 2 protein (SLIT2) ELISA Kit |
|
AE18234MO-96Tests |
Abebio |
96 Tests |
EUR 610 |
|
|
|
Description: Mouse (Mus musculus) |
Mouse Slit homolog 2 protein (SLIT2) ELISA Kit |
|
RK07143 |
Abclonal |
96T |
EUR 280 |
Mouse Slit homolog 2 protein (SLIT2) ELISA Kit |
|
EK7240 |
SAB |
96Т |
EUR 799 |
|
|
) ELISA kit for Rat Slit homolog 2 protein (SLIT2) |
|
KTE100240-48T |
Abbkine |
48T |
EUR 398.4 |
|
|
|
Description: Quantitative sandwich ELISA for measuring Rat Slit homolog 2 protein (SLIT2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Rat Slit homolog 2 protein (SLIT2) |
|
KTE100240-5platesof96wells |
Abbkine |
5 plates of 96 wells |
EUR 2538 |
|
|
|
Description: Quantitative sandwich ELISA for measuring Rat Slit homolog 2 protein (SLIT2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Rat Slit homolog 2 protein (SLIT2) |
|
KTE100240-96T |
Abbkine |
96T |
EUR 646.8 |
|
|
|
Description: Quantitative sandwich ELISA for measuring Rat Slit homolog 2 protein (SLIT2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
) ELISA kit for Mouse Slit2 (Slit Homolog 2) |
|
E-EL-M0819 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 640.8 |
|
|
|
Description: A sandwich ELISA kit for quantitative measurement of Mouse Slit2 (Slit Homolog 2) in samples from Serum, Plasma, Cell supernatant |
ELISA kit for Mouse Slit2 (Slit Homolog 2) |
|
ELK2103 |
ELK Biotech |
1 plate of 96 wells |
EUR 518.4 |
|
|
|
Description: A sandwich ELISA kit for detection of Slit Homolog 2 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
 Slit2 ELISA Kit| Mouse Slit homolog 2 protein ELISA Kit |
|
EF013084 |
Lifescience Market |
96 Tests |
EUR 826.8 |
) ELISA kit for Human Slit homolog 2 protein (SLIT2) |
|
KTE60581-48T |
Abbkine |
48T |
EUR 398.4 |
|
|
|
Description: Quantitative sandwich ELISA for measuring Human Slit homolog 2 protein (SLIT2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Human Slit homolog 2 protein (SLIT2) |
|
KTE60581-5platesof96wells |
Abbkine |
5 plates of 96 wells |
EUR 2538 |
|
|
|
Description: Quantitative sandwich ELISA for measuring Human Slit homolog 2 protein (SLIT2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Human Slit homolog 2 protein (SLIT2) |
|
KTE60581-96T |
Abbkine |
96T |
EUR 646.8 |
|
|
|
Description: Quantitative sandwich ELISA for measuring Human Slit homolog 2 protein (SLIT2) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
 Mouse Slit homolog 3 protein, Slit3 ELISA KIT |
|
ELI-18165m |
Lifescience Market |
96 Tests |
EUR 1038 |
 Mouse Slit homolog 1 protein, Slit1 ELISA KIT |
|
ELI-18718m |
Lifescience Market |
96 Tests |
EUR 1038 |
 ELISA Kit) Mouse Slit homolog 3 protein (SLIT3) ELISA Kit |
|
KTE70415-96T5 |
Abbkine |
96 T×5 |
EUR 2629 |
|
Description: This Mouse Slit homolog 3 protein (SLIT3) ELISA Kit employs a two-site sandwich ELISA to quantitate SLIT3. |
Mouse Slit homolog 3 protein (SLIT3) ELISA Kit |
|
KTE70415-96T50 |
Abbkine |
96 T×50 |
EUR 24569 |
|
Description: This Mouse Slit homolog 3 protein (SLIT3) ELISA Kit employs a two-site sandwich ELISA to quantitate SLIT3. |
Mouse Slit homolog 3 protein (SLIT3) ELISA Kit |
|
AE18231MO-48Tests |
Abebio |
48 Tests |
EUR 325 |
|
|
|
Description: Mouse (Mus musculus) |
Mouse Slit homolog 3 protein (SLIT3) ELISA Kit |
|
AE18231MO-96Tests |
Abebio |
96 Tests |
EUR 610 |
|
|
|
Description: Mouse (Mus musculus) |
 ELISA Kit) Mouse Slit homolog 1 protein (SLIT1) ELISA Kit |
|
AE18239MO-48Tests |
Abebio |
48 Tests |
EUR 325 |
|
|
|
Description: Mouse (Mus musculus) |
Mouse Slit homolog 1 protein (SLIT1) ELISA Kit |
|
AE18239MO-96Tests |
Abebio |
96 Tests |
EUR 610 |
|
|
|
Description: Mouse (Mus musculus) |
Mouse Slit homolog 3 protein (SLIT3) ELISA Kit |
|
EK7237 |
SAB |
96Т |
EUR 799 |
|
|
Mouse Slit homolog 1 protein (SLIT1) ELISA Kit |
|
EK7243 |
SAB |
96Т |
EUR 799 |
|
|
) ELISA kit for Rat Slit homolog 3 protein (SLIT3) |
|
KTE100239-48T |
Abbkine |
48T |
EUR 398.4 |
|
|
|
Description: Quantitative sandwich ELISA for measuring Rat Slit homolog 3 protein (SLIT3) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Rat Slit homolog 3 protein (SLIT3) |
|
KTE100239-5platesof96wells |
Abbkine |
5 plates of 96 wells |
EUR 2538 |
|
|
|
Description: Quantitative sandwich ELISA for measuring Rat Slit homolog 3 protein (SLIT3) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Rat Slit homolog 3 protein (SLIT3) |
|
KTE100239-96T |
Abbkine |
96T |
EUR 646.8 |
|
|
|
Description: Quantitative sandwich ELISA for measuring Rat Slit homolog 3 protein (SLIT3) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
) ELISA kit for Rat Slit homolog 1 protein (SLIT1) |
|
KTE100241-48T |
Abbkine |
48T |
EUR 398.4 |
|
|
|
Description: Quantitative sandwich ELISA for measuring Rat Slit homolog 1 protein (SLIT1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Rat Slit homolog 1 protein (SLIT1) |
|
KTE100241-5platesof96wells |
Abbkine |
5 plates of 96 wells |
EUR 2538 |
|
|
|
Description: Quantitative sandwich ELISA for measuring Rat Slit homolog 1 protein (SLIT1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Rat Slit homolog 1 protein (SLIT1) |
|
KTE100241-96T |
Abbkine |
96T |
EUR 646.8 |
|
|
|
Description: Quantitative sandwich ELISA for measuring Rat Slit homolog 1 protein (SLIT1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
) ELISA kit for Mouse Slit3 (Slit Homolog 3) |
|
ELK7762 |
ELK Biotech |
1 plate of 96 wells |
EUR 518.4 |
|
|
|
Description: A sandwich ELISA kit for detection of Slit Homolog 3 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
) ELISA kit for Mouse Slit1 (Slit Homolog 1) |
|
ELK6408 |
ELK Biotech |
1 plate of 96 wells |
EUR 518.4 |
|
|
|
Description: A sandwich ELISA kit for detection of Slit Homolog 1 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
) ELISA kit for Human Slit homolog 3 protein (SLIT3) |
|
KTE60580-48T |
Abbkine |
48T |
EUR 398.4 |
|
|
|
Description: Quantitative sandwich ELISA for measuring Human Slit homolog 3 protein (SLIT3) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Human Slit homolog 3 protein (SLIT3) |
|
KTE60580-5platesof96wells |
Abbkine |
5 plates of 96 wells |
EUR 2538 |
|
|
|
Description: Quantitative sandwich ELISA for measuring Human Slit homolog 3 protein (SLIT3) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Human Slit homolog 3 protein (SLIT3) |
|
KTE60580-96T |
Abbkine |
96T |
EUR 646.8 |
|
|
|
Description: Quantitative sandwich ELISA for measuring Human Slit homolog 3 protein (SLIT3) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
) ELISA kit for Human Slit homolog 1 protein (SLIT1) |
|
KTE60582-48T |
Abbkine |
48T |
EUR 398.4 |
|
|
|
Description: Quantitative sandwich ELISA for measuring Human Slit homolog 1 protein (SLIT1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Human Slit homolog 1 protein (SLIT1) |
|
KTE60582-5platesof96wells |
Abbkine |
5 plates of 96 wells |
EUR 2538 |
|
|
|
Description: Quantitative sandwich ELISA for measuring Human Slit homolog 1 protein (SLIT1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Human Slit homolog 1 protein (SLIT1) |
|
KTE60582-96T |
Abbkine |
96T |
EUR 646.8 |
|
|
|
Description: Quantitative sandwich ELISA for measuring Human Slit homolog 1 protein (SLIT1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
 Mouse Slit Homolog 2 ELISA kit |
|
E03S0112-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Mouse Slit Homolog 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Slit Homolog 2 ELISA kit |
|
E03S0112-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Mouse Slit Homolog 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Slit Homolog 2 ELISA kit |
|
E03S0112-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Mouse Slit Homolog 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Slit Homolog 2 ELISA kit |
|
E01A25235 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
) ELISA Kit for Slit Homolog 2 (Slit2) |
|
SEA672Hu |
Cloud-Clone |
96Т |
EUR 630 |
|
|
ELISA Kit for Slit Homolog 2 (Slit2) |
|
SEA672Mu |
Cloud-Clone |
96Т |
EUR 648 |
|
|
ELISA Kit for Slit Homolog 2 (Slit2) |
|
SEA672Ra |
Cloud-Clone |
96Т |
EUR 684 |
|
|
 ELISA Kit) Rat Slit homolog 2 protein (SLIT2) ELISA Kit |
|
AE18235RA-48Tests |
Abebio |
48 Tests |
EUR 325 |
|
|
|
Description: Rat (Rattus norvegicus) |
Rat Slit homolog 2 protein (SLIT2) ELISA Kit |
|
AE18235RA-96Tests |
Abebio |
96 Tests |
EUR 610 |
|
|
|
Description: Rat (Rattus norvegicus) |
Rat Slit homolog 2 protein (SLIT2) ELISA Kit |
|
EK7241 |
SAB |
96Т |
EUR 799 |
|
|
 Human Slit homolog 2 protein, SLIT2 ELISA KIT |
|
ELI-02347h |
Lifescience Market |
96 Tests |
EUR 988.8 |
 Human SLIT2/ Slit homolog 2 protein ELISA Kit |
|
E2339Hu |
Sunlong |
1 Kit |
EUR 685.2 |
 ELISA Kit) Human SLIT2(Slit homolog 2 protein) ELISA Kit |
|
EH0999 |
FN Test |
96T |
EUR 628.92 |
|
|
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml |
 ELISA Kit) Human Slit homolog 2 protein (SLIT2) ELISA Kit |
|
KTE60581-96T5 |
Abbkine |
96 T×5 |
EUR 2629 |
|
Description: This Human Slit homolog 2 protein (SLIT2) ELISA Kit employs a two-site sandwich ELISA to quantitate SLIT2. |
Human Slit homolog 2 protein (SLIT2) ELISA Kit |
|
KTE60581-96T50 |
Abbkine |
96 T×50 |
EUR 24569 |
|
Description: This Human Slit homolog 2 protein (SLIT2) ELISA Kit employs a two-site sandwich ELISA to quantitate SLIT2. |
Human Slit homolog 2 protein (SLIT2) ELISA Kit |
|
AE18237HU-48Tests |
Abebio |
48 Tests |
EUR 325 |
|
|
|
Description: Human (Homo sapiens) |
Human Slit homolog 2 protein (SLIT2) ELISA Kit |
|
AE18237HU-96Tests |
Abebio |
96 Tests |
EUR 610 |
|
|
|
Description: Human (Homo sapiens) |
) CLIA kit for Mouse Slit2 (Slit Homolog 2) |
|
E-CL-M0508 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 700.8 |
|
|
|
Description: A sandwich CLIA kit for quantitative measurement of Mouse Slit2 (Slit Homolog 2) in samples from Serum, Plasma, Cell supernatant |
 Protein) Mouse Slit Homolog 2 (Slit2) Protein |
|
20-abx069121 |
Abbexa |
-
EUR 844.80
-
EUR 343.20
-
EUR 2614.80
-
EUR 1011.60
-
EUR 610.80
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
|
Mouse Slit Homolog 2 (Slit2) Protein |
|
20-abx168430 |
Abbexa |
-
EUR 844.80
-
EUR 343.20
-
EUR 2614.80
-
EUR 1011.60
-
EUR 610.80
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
|
 ELISA Kit) Mouse Slit Homolog 2 (Slit2) ELISA Kit |
|
abx254788-96tests |
Abbexa |
96 tests |
EUR 801.6 |
|
|
Mouse Slit Homolog 2 (Slit2) ELISA Kit |
|
20-abx154689 |
Abbexa |
-
EUR 7970.40
-
EUR 4250.40
-
EUR 990.00
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
|
Mouse Slit Homolog 2 (Slit2) ELISA Kit |
|
abx051309-96tests |
Abbexa |
96 tests |
EUR 943.2 |
|
|
Mouse Slit Homolog 2 (Slit2) ELISA Kit |
|
abx576307-96tests |
Abbexa |
96 tests |
EUR 801.6 |
|
|
Mouse Slit Homolog 2 (Slit2) ELISA Kit |
|
DLR-Slit2-Mu-48T |
DL Develop |
48T |
EUR 586.8 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Slit Homolog 2 (Slit2) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids. |
Mouse Slit Homolog 2 (Slit2) ELISA Kit |
|
DLR-Slit2-Mu-96T |
DL Develop |
96T |
EUR 762 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Slit Homolog 2 (Slit2) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids. |
Mouse Slit Homolog 2 (Slit2) ELISA Kit |
|
RDR-Slit2-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 613.2 |
Mouse Slit Homolog 2 (Slit2) ELISA Kit |
|
RDR-Slit2-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 850.8 |
Mouse Slit Homolog 2 (Slit2) ELISA Kit |
|
RD-Slit2-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 586.8 |
Mouse Slit Homolog 2 (Slit2) ELISA Kit |
|
RD-Slit2-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 812.4 |
Mouse Slit Homolog 2 (Slit2) ELISA Kit |
|
RDR-Slit2-Mu-48T |
Reddot Biotech |
48T |
EUR 443.42 |
|
|
|
Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
Mouse Slit Homolog 2 (Slit2) ELISA Kit |
|
RDR-Slit2-Mu-96T |
Reddot Biotech |
96T |
EUR 633.47 |
|
|
|
Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
Mouse Slit Homolog 2 (Slit2) ELISA Kit |
|
RD-Slit2-Mu-48T |
Reddot Biotech |
48T |
EUR 422.3 |
|
|
|
Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
Mouse Slit Homolog 2 (Slit2) ELISA Kit |
|
RD-Slit2-Mu-96T |
Reddot Biotech |
96T |
EUR 603.3 |
|
|
|
Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
Mouse Slit Homolog 2 (Slit2) ELISA Kit |
|
SEA672Mu-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 5269.39 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Slit Homolog 2 (Slit2) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
Mouse Slit Homolog 2 (Slit2) ELISA Kit |
|
SEA672Mu-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 539.12 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Slit Homolog 2 (Slit2) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
Mouse Slit Homolog 2 (Slit2) ELISA Kit |
|
SEA672Mu-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 718.75 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Slit Homolog 2 (Slit2) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
Mouse Slit Homolog 2 (Slit2) ELISA Kit |
|
SEA672Mu-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 2874.38 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Slit Homolog 2 (Slit2) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
Mouse Slit Homolog 2 (Slit2) ELISA Kit |
|
4-SEA672Mu |
Cloud-Clone |
-
EUR 5330.40
-
EUR 2815.20
-
EUR 718.80
|
- 10 plates of 96 wells
- 5 plates of 96 wells
- 1 plate of 96 wells
|
|
|
|
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Slit Homolog 2 (Slit2) in samples from serum, plasma, tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. |
ELISA Kit) Mouse Slit Homolog 2 (Slit2)ELISA Kit |
|
NSL1284m |
Sunlong |
96 Test |
EUR 528 |
|
|
 ELISA Kit) Mouse Slit2(Slit Homolog 2) ELISA Kit |
|
ELK2103-48T |
ELK Biotech |
48T |
Ask for price |
|
|
|
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse Slit2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse Slit2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse Slit2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse Slit2 in the samples is then determined by comparing the OD of the samples to the standard curve. |
Mouse Slit2(Slit Homolog 2) ELISA Kit |
|
ELK2103-96T |
ELK Biotech |
96T |
Ask for price |
|
|
|
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse Slit2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse Slit2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse Slit2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse Slit2 in the samples is then determined by comparing the OD of the samples to the standard curve. |
Mouse Slit Homolog 2 (Slit2) ELISA Kit |
|
DL-Slit2-Mu |
DL Develop |
96T |
EUR 412 |
|
|
|
Description: serum, plasma, tissue homogenates, cell lysates or other biological fluids. |
Mouse Slit Homolog 2 (Slit2) ELISA Kit |
|
DLR-Slit2-Mu |
DL Develop |
96T |
EUR 432 |
|
|
|
Description: serum, plasma, tissue homogenates, cell lysates or other biological fluids. |
Mouse Slit Homolog 2 (Slit2) ELISA Kit |
|
EK16660 |
SAB |
96Т |
EUR 768 |
|
|
Mouse Slit2(Slit Homolog 2) ELISA Kit |
|
RE1524M-48wells |
Reed Biotech |
48 wells |
EUR 116.55 |
|
|
Mouse Slit2(Slit Homolog 2) ELISA Kit |
|
RE1524M-96wells |
Reed Biotech |
96 wells |
EUR 161.55 |
|
|
) ELISA kit for Rat SLIT2 (Slit Homolog 2) |
|
E-EL-R0886 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 640.8 |
|
|
|
Description: A sandwich ELISA kit for quantitative measurement of Rat SLIT2 (Slit Homolog 2) in samples from Serum, Plasma, Cell supernatant |
) ELISA kit for Rat Slit2 (Slit Homolog 2) |
|
ELK2972 |
ELK Biotech |
1 plate of 96 wells |
EUR 518.4 |
|
|
|
Description: A sandwich ELISA kit for detection of Slit Homolog 2 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
) ELISA kit for Human Slit2 (Slit Homolog 2) |
|
E-EL-H0931 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 640.8 |
|
|
|
Description: A sandwich ELISA kit for quantitative measurement of Human Slit2 (Slit Homolog 2) in samples from Serum, Plasma, Cell supernatant |
ELISA kit for Human Slit2 (Slit Homolog 2) |
|
ELK2102 |
ELK Biotech |
1 plate of 96 wells |
EUR 518.4 |
|
|
|
Description: A sandwich ELISA kit for detection of Slit Homolog 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
 Mouse Slit Homolog 1 ELISA Kit |
|
IMSSLIT1KT |
Innovative research |
each |
EUR 752 |
|
|
|
Description: Mouse Slit Homolog 1 ELISA Kit |
 Mouse Slit Homolog 3 ELISA Kit |
|
IMSSLIT3KT |
Innovative research |
each |
EUR 752 |
|
|
|
Description: Mouse Slit Homolog 3 ELISA Kit |
 Mouse Slit Homolog 3 ELISA kit |
|
E01A25534 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
) ELISA Kit for Slit Homolog 3 (Slit3) |
|
SED353Hu |
Cloud-Clone |
96Т |
EUR 700 |
|
|
ELISA Kit for Slit Homolog 3 (Slit3) |
|
SED353Mi |
Cloud-Clone |
96Т |
EUR 720 |
|
|
ELISA Kit for Slit Homolog 3 (Slit3) |
|
SED353Mu |
Cloud-Clone |
96Т |
EUR 720 |
|
|
ELISA Kit for Slit Homolog 3 (Slit3) |
|
SED353Ra |
Cloud-Clone |
96Т |
EUR 760 |
|
|
) ELISA Kit for Slit Homolog 1 (Slit1) |
|
SED354Hu |
Cloud-Clone |
96Т |
EUR 700 |
|
|
ELISA Kit for Slit Homolog 1 (Slit1) |
|
SED354Mu |
Cloud-Clone |
96Т |
EUR 720 |
|
|
ELISA Kit for Slit Homolog 1 (Slit1) |
|
SED354Ra |
Cloud-Clone |
96Т |
EUR 760 |
|
|
 ELISA Kit) Rat Slit homolog 3 protein (SLIT3) ELISA Kit |
|
AE18232RA-48Tests |
Abebio |
48 Tests |
EUR 325 |
|
|
|
Description: Rat (Rattus norvegicus) |
Rat Slit homolog 3 protein (SLIT3) ELISA Kit |
|
AE18232RA-96Tests |
Abebio |
96 Tests |
EUR 610 |
|
|
|
Description: Rat (Rattus norvegicus) |
 ELISA Kit) Rat Slit homolog 1 protein (SLIT1) ELISA Kit |
|
AE18238RA-48Tests |
Abebio |
48 Tests |
EUR 325 |
|
|
|
Description: Rat (Rattus norvegicus) |
Rat Slit homolog 1 protein (SLIT1) ELISA Kit |
|
AE18238RA-96Tests |
Abebio |
96 Tests |
EUR 610 |
|
|
|
Description: Rat (Rattus norvegicus) |
Rat Slit homolog 3 protein (SLIT3) ELISA Kit |
|
EK7238 |
SAB |
96Т |
EUR 799 |
|
|
Rat Slit homolog 1 protein (SLIT1) ELISA Kit |
|
EK7242 |
SAB |
96Т |
EUR 799 |
|
|
 ELISA kit) Human Slit homolog 3 protein(SLIT3) ELISA kit |
|
CSB-EL021769HU-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
|
|
Description: Quantitativesandwich ELISA kit for measuring Human Slit homolog 3 protein (SLIT3) in samples from serum, plasma, cell culture supernates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human Slit homolog 3 protein(SLIT3) ELISA kit |
|
1-CSB-EL021769HU |
Cusabio |
-
EUR 964.80
-
EUR 6118.80
-
EUR 3244.80
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
|
|
Description: Quantitativesandwich ELISA kit for measuring Human Slit homolog 3 protein(SLIT3) in samples from serum, plasma, cell culture supernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
 Human Slit homolog 3 protein, SLIT3 ELISA KIT |
|
ELI-52340h |
Lifescience Market |
96 Tests |
EUR 988.8 |
 Human Slit homolog 1 protein, SLIT1 ELISA KIT |
|
ELI-18717h |
Lifescience Market |
96 Tests |
EUR 988.8 |
 ELISA Kit) Human Slit homolog 3 protein (SLIT3) ELISA Kit |
|
KTE60580-96T5 |
Abbkine |
96 T×5 |
EUR 2629 |
|
Description: This Human Slit homolog 3 protein (SLIT3) ELISA Kit employs a two-site sandwich ELISA to quantitate SLIT3. |
Human Slit homolog 3 protein (SLIT3) ELISA Kit |
|
KTE60580-96T50 |
Abbkine |
96 T×50 |
EUR 24569 |
|
Description: This Human Slit homolog 3 protein (SLIT3) ELISA Kit employs a two-site sandwich ELISA to quantitate SLIT3. |
 ELISA Kit) Human Slit homolog 1 protein (SLIT1) ELISA Kit |
|
KTE60582-96T5 |
Abbkine |
96 T×5 |
EUR 2629 |
|
Description: This Human Slit homolog 1 protein (SLIT1) ELISA Kit employs a two-site sandwich ELISA to quantitate SLIT1. |
Human Slit homolog 1 protein (SLIT1) ELISA Kit |
|
KTE60582-96T50 |
Abbkine |
96 T×50 |
EUR 24569 |
|
Description: This Human Slit homolog 1 protein (SLIT1) ELISA Kit employs a two-site sandwich ELISA to quantitate SLIT1. |
Human Slit homolog 3 protein (SLIT3) ELISA Kit |
|
AE18233HU-48Tests |
Abebio |
48 Tests |
EUR 325 |
|
|
|
Description: Human (Homo sapiens) |
Human Slit homolog 3 protein (SLIT3) ELISA Kit |
|
AE18233HU-96Tests |
Abebio |
96 Tests |
EUR 610 |
|
|
|
Description: Human (Homo sapiens) |
Human Slit homolog 1 protein (SLIT1) ELISA Kit |
|
AE18240HU-48Tests |
Abebio |
48 Tests |
EUR 325 |
|
|
|
Description: Human (Homo sapiens) |
Human Slit homolog 1 protein (SLIT1) ELISA Kit |
|
AE18240HU-96Tests |
Abebio |
96 Tests |
EUR 610 |
|
|
|
Description: Human (Homo sapiens) |
Human Slit homolog 3 protein (SLIT3) ELISA Kit |
|
RK12255 |
Abclonal |
96T |
EUR 280 |
 Elisa Kit) Human Slit homolog 3 protein(SLIT3) Elisa Kit |
|
EK713745 |
AFG Bioscience LLC |
96 Wells |
EUR 0.39 |
 Elisa Kit) Human Slit homolog 1 protein(SLIT1) Elisa Kit |
|
EK713746 |
AFG Bioscience LLC |
96 Wells |
EUR 0.39 |
Human Slit homolog 3 protein (SLIT3) ELISA Kit |
|
EK7239 |
SAB |
96Т |
EUR 799 |
|
|
Human Slit homolog 1 protein (SLIT1) ELISA Kit |
|
EK7244 |
SAB |
96Т |
EUR 799 |
|
|
 Slit homolog 2 protein |
|
AP87788 |
SAB |
1mg |
EUR 2640 |
|
|
Slit homolog 2 protein |
|
AP78611 |
SAB |
1mg |
EUR 2640 |
|
|
Slit homolog 2 protein |
|
AP87974 |
SAB |
1mg |
EUR 2640 |
|
|
 ELISA Kit) Mouse Slit Homolog 1 (Slit1) ELISA Kit |
|
20-abx154688 |
Abbexa |
-
EUR 8853.60
-
EUR 4719.60
-
EUR 1093.20
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
|
 ELISA Kit) Mouse Slit Homolog 3 (Slit3) ELISA Kit |
|
20-abx154690 |
Abbexa |
-
EUR 8853.60
-
EUR 4719.60
-
EUR 1093.20
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
|
Mouse Slit Homolog 1 (Slit1) ELISA Kit |
|
DLR-Slit1-Mu-48T |
DL Develop |
48T |
EUR 632.4 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Slit Homolog 1 (Slit1) in samples from serum, plasma, tissue homogenates or other biological fluids. |
Mouse Slit Homolog 1 (Slit1) ELISA Kit |
|
DLR-Slit1-Mu-96T |
DL Develop |
96T |
EUR 825.6 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Slit Homolog 1 (Slit1) in samples from serum, plasma, tissue homogenates or other biological fluids. |
Mouse Slit Homolog 3 (Slit3) ELISA Kit |
|
DLR-Slit3-Mu-48T |
DL Develop |
48T |
EUR 632.4 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Slit Homolog 3 (Slit3) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Mouse Slit Homolog 3 (Slit3) ELISA Kit |
|
DLR-Slit3-Mu-96T |
DL Develop |
96T |
EUR 825.6 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Slit Homolog 3 (Slit3) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Mouse Slit Homolog 1 (Slit1) ELISA Kit |
|
RDR-Slit1-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 668.4 |
Mouse Slit Homolog 1 (Slit1) ELISA Kit |
|
RDR-Slit1-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 928.8 |
Mouse Slit Homolog 3 (Slit3) ELISA Kit |
|
RDR-Slit3-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 668.4 |
Mouse Slit Homolog 3 (Slit3) ELISA Kit |
|
RDR-Slit3-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 928.8 |
Mouse Slit Homolog 1 (Slit1) ELISA Kit |
|
RD-Slit1-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 639.6 |
Mouse Slit Homolog 1 (Slit1) ELISA Kit |
|
RD-Slit1-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 888 |
Mouse Slit Homolog 3 (Slit3) ELISA Kit |
|
RD-Slit3-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 639.6 |
Mouse Slit Homolog 3 (Slit3) ELISA Kit |
|
RD-Slit3-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 888 |
) Mouse Slit Homolog 3 ELISA Kit (Slit3) |
|
RK03196 |
Abclonal |
96 Tests |
EUR 625.2 |
Mouse Slit Homolog 1 (Slit1) ELISA Kit |
|
RDR-Slit1-Mu-48T |
Reddot Biotech |
48T |
EUR 487.52 |
|
|
|
Description: serum, plasma, tissue homogenates and other biological fluids. |
Mouse Slit Homolog 1 (Slit1) ELISA Kit |
|
RDR-Slit1-Mu-96T |
Reddot Biotech |
96T |
EUR 696.47 |
|
|
|
Description: serum, plasma, tissue homogenates and other biological fluids. |
Mouse Slit Homolog 3 (Slit3) ELISA Kit |
|
RDR-Slit3-Mu-48T |
Reddot Biotech |
48T |
EUR 487.52 |
|
|
|
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. |
Mouse Slit Homolog 3 (Slit3) ELISA Kit |
|
RDR-Slit3-Mu-96T |
Reddot Biotech |
96T |
EUR 696.47 |
|
|
|
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. |
Mouse Slit Homolog 1 (Slit1) ELISA Kit |
|
RD-Slit1-Mu-48T |
Reddot Biotech |
48T |
EUR 464.3 |
|
|
|
Description: serum, plasma, tissue homogenates and other biological fluids. |
Mouse Slit Homolog 1 (Slit1) ELISA Kit |
|
RD-Slit1-Mu-96T |
Reddot Biotech |
96T |
EUR 663.3 |
|
|
|
Description: serum, plasma, tissue homogenates and other biological fluids. |
Mouse Slit Homolog 3 (Slit3) ELISA Kit |
|
RD-Slit3-Mu-48T |
Reddot Biotech |
48T |
EUR 464.3 |
|
|
|
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. |
Mouse Slit Homolog 3 (Slit3) ELISA Kit |
|
RD-Slit3-Mu-96T |
Reddot Biotech |
96T |
EUR 663.3 |
|
|
|
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. |
Mouse Slit Homolog 3 (Slit3) ELISA Kit |
|
SED353Mu-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 5834.88 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Slit Homolog 3 (Slit3) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
Mouse Slit Homolog 3 (Slit3) ELISA Kit |
|
SED353Mu-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 585.7 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Slit Homolog 3 (Slit3) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
Mouse Slit Homolog 3 (Slit3) ELISA Kit |
|
SED353Mu-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 785.28 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Slit Homolog 3 (Slit3) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
Mouse Slit Homolog 3 (Slit3) ELISA Kit |
|
SED353Mu-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 3173.76 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Slit Homolog 3 (Slit3) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
Mouse Slit Homolog 3 (Slit3) ELISA Kit |
|
4-SED353Mu |
Cloud-Clone |
-
EUR 5895.60
-
EUR 3114.00
-
EUR 786.00
|
- 10 plates of 96 wells
- 5 plates of 96 wells
- 1 plate of 96 wells
|
|
|
|
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Slit Homolog 3 (Slit3) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. |
Beneath physiological situations, cortex glial Hh is autonomously required to maintain area of interest chamber formation. Upon FGF-mediated cortex glial overgrowth, glial Hh non-autonomously prompts Hh signalling within the NBs, which in flip disrupts NB cell cycle development and its potential to provide neurons. Glial Hh’s potential to sign to NB is additional modulated by lipid storage regulator lipid storage droplet-2 (Lsd-2) and de novo lipogenesis gene fatty acid synthase 1 (Fasn1). Collectively, our knowledge recommend that glial-derived Hh modified by lipid metabolism mechanisms can have an effect on the neighbouring NB’s potential to proliferate and produce neurons.
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